3D inkjet printing is a fast, reliable, and non‐contact bottom–up approach to printing small and large models and is one of the fastest additive manufacturing technologies available. These attributes position inkjet printing as a promising tool for the additive manufacturing of biomaterials, for example, tissue engineering scaffolds. However, due to the stringent technical rheological requirements of current inkjet technologies, there is a lack of photopolymer resins suitable for the inkjet printing of biomaterials. Hence, a novel ink engineered for 3D piezoelectric inkjet printing of biomaterials is designed and developed. The novel resin leverages a biodegradable amino acid phosphorodiamidate matrix copolymerized with a dialkyne ether to modulate the viscosity. Copolymerization with commercially available thiols facilitates the photochemical thiol‐yne curing reaction. The ink exhibits optimal viscosity, eliminating the need for solvents, as well as reliable jetting and sufficiently swift curing kinetics. Furthermore, the formulation is successfully demonstrated in an industrial inkjet printhead. Notably, the resulting materials have low cytotoxicity and, hence, have significant promise in advancing the applications of 3D inkjet printing of biological scaffolds.

中文翻译：

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使用无溶剂硫醇基光固化油墨对生物材料进行 3D 喷墨打印

3D 喷墨打印是一种快速、可靠、非接触式自下而上打印小型和大型模型的方法，也是最快的增材制造技术之一。这些属性使喷墨打印成为生物材料（例如组织工程支架）增材制造的有前途的工具。然而，由于当前喷墨技术对技术流变性的严格要求，缺乏适合生物材料喷墨打印的光敏聚合物树脂。因此，设计和开发了一种用于生物材料 3D 压电喷墨打印的新型墨水。这种新型树脂利用可生物降解的氨基酸二氨基磷酸酯基质与二炔醚共聚来调节粘度。与市售硫醇的共聚促进了光化学硫醇-炔固化反应。该油墨具有最佳的粘度，无需溶剂，并且具有可靠的喷射和足够快速的固化动力学。此外，该配方已在工业喷墨打印头中成功得到验证。值得注意的是，所得材料具有低细胞毒性，因此在推进生物支架3D喷墨打印的应用方面具有重大前景。