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Identification of a cold sensor in peripheral somatosensory neurons
Nature Neuroscience ( IF 25.0 ) Pub Date : 2024-03-11 , DOI: 10.1038/s41593-024-01606-6


Cold sensor identities in peripheral somatosensory neurons remain obscure. We show that GluK2, a kainate-type glutamate-sensing chemoreceptor that mediates synaptic transmission in the brain, mediates the sensing of cold but not cool temperatures in mouse dorsal root ganglia neurons in the periphery. Thus, we identify GluK2 as a cold-sensing thermoreceptor.

中文翻译:

外周体感神经元中冷传感器的识别

外周体感神经元中的冷传感器身份仍然模糊。我们发现,GluK2 是一种红藻氨酸型谷氨酸感应化学感受器,可介导大脑中的突触传递,介导小鼠外周背根神经节神经元对冷温度的感知,但不介导低温的感知。因此,我们将 GluK2 鉴定为冷感温度感受器。
更新日期:2024-03-12
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