Salmonella enterica serovar Abortusovis is a host-adapted pathogen that causes spontaneous abortion. Salmonella Abortusovis was reported in poultry in 2009 and has since been reported in human infections in New South Wales, Australia. Phylogenomic analysis revealed a clade of 51 closely related isolates from Australia originating in 2004. That clade was genetically distinct from ovine-associated isolates. The clade was widespread in New South Wales poultry production facilities but was only responsible for sporadic human infections. Some known virulence factors associated with human infections were only found in the poultry-associated clade, some of which were acquired through prophages and plasmids. Furthermore, the ovine-associated clade showed signs of genome decay, but the poultry-associated clade did not. Those genomic changes most likely led to differences in host range and disease type. Surveillance using the newly identified genetic markers will be vital for tracking Salmonella Abortusovis transmission in animals and to humans and preventing future outbreaks.

流产沙门氏菌是一种导致自然流产的宿主适应病原体。2009 年在家禽中发现了流产沙门氏菌，此后在澳大利亚新南威尔士州也报告了人类感染。系统发育基因组分析揭示了 2004 年来自澳大利亚的 51 个密切相关的分离株的进化枝。该进化枝在遗传上与绵羊相关分离株不同。该分支在新南威尔士州的家禽生产设施中广泛存在，但仅造成零星的人类感染。一些已知的与人类感染相关的毒力因子仅在家禽相关的进化枝中发现，其中一些是通过原噬菌体和质粒获得的。此外，与绵羊相关的进化枝显示出基因组衰退的迹象，但与家禽相关的进化枝却没有。这些基因组变化很可能导致宿主范围和疾病类型的差异。使用新发现的遗传标记进行监测对于追踪流产沙门氏菌在动物和人类中的传播以及预防未来的爆发至关重要。