PurposeThis study aimed to investigate the association between oxidative balance score (OBS), wherein higher OBSs indicate lower oxidative stress, and high‐sensitivity C‐reactive protein (hs‐CRP), as well as inflammatory scores, in a large cohort of Japanese adults.MethodsIn total, 9703 individuals aged 40–69 years participated in a baseline survey of a population‐based cohort study in Saga, Japan (2005–2007). OBSs were calculated from 11 prooxidant and antioxidant lifestyle factors, including dietary intake, physical activity, alcohol consumption, and smoking status. Lifestyle data, including dietary intake, were obtained using a self‐administered questionnaire. Adjusted geometric means of serum hs‐CRP levels were calculated based on OBS quartiles, and linear trend tests were performed, with adjustments for potential confounders. In addition, an inflammatory cytokine z‐score was constructed and assessed alongside individual markers.ResultsAfter adjusting for multiple confounders in both sexes, the results showed a significant inverse association between OBS and serum hs‐CRP levels in both men and women. These results remained unaltered when the OBS evaluation excluded powerful prooxidants, serum ferritin, or smoking. There was also an association between OBS and lower inflammatory z‐score, indicating reduced overall systemic inflammation.ConclusionsThese findings suggest that a higher OBS, indicating a greater predominance of antioxidants over prooxidant exposure, is associated with lower hs‐CRP levels and reduced systemic inflammation, regardless of sex.

中文翻译：

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日本中老年人氧化平衡评分与炎症标志物的关联

目的本研究旨在调查一大群日本成年人的氧化平衡评分 (OBS)（其中较高的 OBS 表明氧化应激较低）与高敏 C 反应蛋白 (hs-CRP) 以及炎症评分之间的关​​联方法总共有 9703 名 40-69 岁的个体参加了日本佐贺市一项基于人群的队列研究的基线调查（2005-2007 年）。OBS 是根据 11 种促氧化剂和抗氧化剂生活方式因素计算得出的，包括饮食摄入量、体力活动、饮酒量和吸烟状况。生活方式数据，包括饮食摄入量，是通过自填问卷获得的。根据OBS四分位数计算调整后的血清hs-CRP水平的几何平均值，并进行线性趋势检验，并对潜在的混杂因素进行调整。此外，还有一种炎症细胞因子z‐分数与个体标记一起构建和评估。结果在调整两性的多个混杂因素后，结果显示男性和女性的 OBS 和血清 hs-CRP 水平之间存在显着的负相关。当 OBS 评估排除强氧化剂、血清铁蛋白或吸烟时，这些结果保持不变。OBS 与较低的炎症水平之间也存在关联。z‐分数，表明总体系统炎症减少。结论这些发现表明，较高的 OBS（表明抗氧化剂相对于促氧化剂暴露的优势更大）与较低的 hs-CRP 水平和减少的系统炎症相关，无论性别如何。