BackgroundDevelopment of the gonads during fetal life is complex and vital for adult reproductive health. Cell and animal studies have shown an alarming effect of mild analgesics on germ cells in both males and females. More than 50% of pregnant women use mild analgesics during pregnancy, which potentially could compromise the reproductive health of the next generation.ObjectivesWe present a research protocol designed to evaluate the effect of prenatal exposure to mild analgesics and endocrine‐disrupting chemicals on gonadal function in the offspring.PopulationHealthy, singleton pregnant women and their partners.DesignThe COPANA cohort is a prospective, observational pregnancy and birth cohort.MethodsParticipants were enrolled during the first trimester of pregnancy. Information on the use of mild analgesics was collected retrospectively 3 months prior to pregnancy and prospectively every 2 weeks throughout the study. We collected extensive data on lifestyle and reproductive health. Biospecimens were collected in the first trimester (maternal and paternal urine‐ and blood samples), in the third trimester in conjunction with a study‐specific ultrasound scan (maternal urine sample), and approximately 3 months post‐partum during the infant minipuberty period (maternal and infant urine‐ and blood samples). A comprehensive evaluation of reproductive function in the infants during the minipuberty phase was performed, including an ultrasound scan of the testis or ovaries and uterus.Preliminary ResultsIn total, 685 pregnant women and their partners were included between March 2020 and January 2022. A total of 589 infants (287 males) and their parents completed the follow‐up during the minipuberty phase (December 2020—November 2022).ConclusionsThe Copenhagen Analgesic Study holds the potential to provide novel and comprehensive insights into the impact of early and late prenatal exposure to mild analgesics and other endocrine‐disrupting chemicals on future reproductive function in the offspring.

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队列简介：哥本哈根镇痛研究 — COPANA 队列

背景胎儿期性腺的发育非常复杂，对于成人生殖健康至关重要。细胞和动物研究表明，温和的镇痛药对男性和女性的生殖细胞都有令人震惊的影响。超过 50% 的孕妇在怀孕期间使用温和的镇痛药，这可能会损害下一代的生殖健康。 目的我们提出了一项研究方案，旨在评估产前接触温和镇痛药和内分泌干扰化学物质对性腺功能的影响后代。人口健康、单胎孕妇及其伴侣。设计 COPANA 队列是一个前瞻性、观察性怀孕和出生队列。方法参与者在怀孕的前三个月入组。在怀孕前 3 个月回顾性收集有关温和镇痛药使用的信息，并在整个研究过程中每两周前瞻性收集一次。我们收集了有关生活方式和生殖健康的大量数据。生物样本是在妊娠早期（母亲和父亲的尿液和血液样本）、妊娠晚期结合研究特定的超声扫描（母亲尿液样本）以及产后大约 3 个月的婴儿小青春期收集的。母体和婴儿的尿液和血液样本）。对小青春期婴儿的生殖功能进行了全面评估，包括对睾丸或卵巢和子宫进行超声扫描。 初步结果 2020 年 3 月至 2022 年 1 月期间，总共纳入了 685 名孕妇及其伴侣。 589 名婴儿（287 名男性）及其父母在小青春期阶段（2020 年 12 月至 2022 年 11 月）完成了随访。结论哥本哈根镇痛研究有可能为产前早期和晚期接触温和的影响提供新颖和全面的见解。镇痛药和其他内分泌干扰化学物质对后代未来生殖功能的影响。