Urolithin A (UA), a gut-microbiota-derived metabolite of ellagic acid, presents various benefits to intestinal microecology. The presence of “gut-muscle axis” regulating the onset and progression of exercise-related physical frailty and sarcopenia has been recently hypothesized. This study aims to explore the underlying mechanism of gut-muscle axis by which UA enhances muscle strength and fatigue resistance of sleep-deprived (SD) mice.

中文翻译：

---

从肠肌轴的角度来看，尿石素 A 可改善睡眠不足时的运动能力和肠道微生物群

尿石素 A (UA) 是一种源自肠道微生物群的鞣花酸代谢产物，对肠道微生态具有多种益处。最近假设存在“肠-肌肉轴”调节与运动相关的身体虚弱和肌肉减少症的发生和进展。本研究旨在探讨 UA 增强睡眠剥夺 (SD) 小鼠肌肉力量和抗疲劳能力的肠肌轴的潜在机制。