Medical Oncology ( IF 3.4 ) Pub Date : 2024-03-12 , DOI: 10.1007/s12032-024-02308-6 Peipei Wang , Yan Pan , Yu Zhang , Congliang Chen , Junmei Hu , Xia Wang
Human interferon-induced transmembrane protein family (IFITMs) consists of five main proteins. IFITM1, IFITM2, and IFITM3 can be induced by interferon, while IFITM5 and IFITM10 are insensitive to interferon. IFITMs has various functions, including well-researched antiviral effects. As a molecule whose expression is significantly increased by interferon in the immune microenvironment, IFITMs has drawn growing interest in recent years for their role in the cancer progression. Unlike antiviral effects, the role and mechanism of IFITMs in cancer progression have not been clearly studied, especially the role and molecular mechanism of IFITMs in pancreatic cancer are rarely reported in the literature. This article focuses on the role and potential mechanism of IFITMs in pancreatic cancer progression by analyzing the function and mechanism of IFITM1-3 in other cancers and conducting bioinformatics analysis using the databases, so as to provide a new target for pancreatic cancer therapy.
中文翻译:
干扰素诱导的跨膜蛋白家族在癌症进展中的作用:特别关注胰腺癌
人干扰素诱导跨膜蛋白家族 (IFITM) 由五种主要蛋白组成。IFITM1、IFITM2和IFITM3可以被干扰素诱导,而IFITM5和IFITM10对干扰素不敏感。IFITM 具有多种功能,包括经过充分研究的抗病毒作用。作为免疫微环境中干扰素表达显着增加的分子,IFITMs 近年来因其在癌症进展中的作用而引起了越来越多的关注。与抗病毒作用不同,IFITMs在癌症进展中的作用和机制尚未得到明确研究,尤其是IFITMs在胰腺癌中的作用和分子机制鲜有文献报道。本文通过分析IFITM1-3在其他癌症中的功能和机制,并利用数据库进行生物信息学分析,重点探讨IFITMs在胰腺癌进展中的作用和潜在机制,为胰腺癌治疗提供新靶点。