The systemic effects of the artificial sweetener sorbitol on older adult individuals have not been elucidated. We assessed the effects of sorbitol consumption on cognitive and gingival health in a mouse model. Aged mice were fed 5% sorbitol for 3 months before their behavior was assessed, and brain and gingival tissues were collected. Long‐term sorbitol consumption inhibited gingival tissue aging in aged mice. However, it caused cognitive decline and decreased brain‐derived neurotrophic factor (BDNF) in the hippocampus. Sorbitol consumption did not affect homeostatic function; however, it may exert effects within the brain, particularly in the hippocampus.

中文翻译：

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长期摄入山梨醇会影响老年小鼠的海马体并改变认知功能

人工甜味剂山梨糖醇对老年人的全身影响尚未阐明。我们在小鼠模型中评估了山梨醇消耗对认知和牙龈健康的影响。老年小鼠被喂食 5% 山梨醇 3 个月，然后评估其行为，并收集大脑和牙龈组织。长期食用山梨醇可抑制老年小鼠的牙龈组织老化。然而，它会导致认知能力下降并减少海马体中的脑源性神经营养因子（BDNF）。山梨醇的消耗不会影响体内平衡功能；然而，它可能会对大脑产生影响，特别是在海马体中。