This study aimed to determine whether red cell distribution width (RDW) is associated with coronary calcification. A total of 4796 patients who underwent coronary computed tomography angiography and subsequent invasive coronary angiography were consecutively enrolled. Coronary artery calcium score (CACS), demographic, clinical, and laboratory data were collected from electronic medical records. RDW were expressed in two forms, as a coefficient of variation (CV) or as a standard deviation (SD). Multivariable ordinal logistic regression was used to investigate the association of RDW with CACS grades (CACS 0–99, 100–399, 400–999, and >1000). A significant association was found between elevated RDW-SD and higher CACS grades after full adjustment (adjusted OR per 1-SD increase: 1.11, 95% CI: 1.05–1.18; P < .001), while no significant association was found between RDW-CV and CACS grades. When RDW-SD was analyzed as a categorical variable, it was primarily the 4th quartile of RDW-SD that was associated with elevated CACS grades compared with the 1st quartile (adjusted OR: 1.25, 95% CI: 1.07–1.46; P = .006), while the 2nd and 3rd quartiles showed no significantly higher risk. RDW-SD is a more robust biomarker for coronary calcification compared with RDW-CV.

中文翻译：

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转诊进行侵入性冠状动脉造影的患者红细胞分布宽度与冠状动脉钙化之间的关联

本研究旨在确定红细胞分布宽度（RDW）是否与冠状动脉钙化相关。共有4796名接受冠状动脉计算机断层扫描血管造影和随后的侵入性冠状动脉造影的患者连续入组。从电子病历中收集冠状动脉钙化评分（CACS）、人口统计、临床和实验室数据。RDW 以两种形式表示，即变异系数 (CV) 或标准差 (SD)。使用多变量序数逻辑回归研究 RDW 与 CACS 等级（CACS 0-99、100-399、400-999 和 >1000）的关联。完全调整后，发现升高的 RDW-SD 与较高的 CACS 等级之间存在显着相关性（每增加 1-SD 调整后的 OR：1.11，95% CI：1.05–1.18；P < .001），而 RDW 之间未发现显着相关性-CV 和 CACS 等级。当 RDW-SD 作为分类变量进行分析时，主要是 4th与 1 相比，与 CACS 等级升高相关的 RDW-SD 四分位数英石四分位数（调整后 OR：1.25，95% CI：1.07–1.46；P = .006），而 2ND和 3RD四分位数没有显示出明显更高的风险。与 RDW-CV 相比，RDW-SD 是冠状动脉钙化的更稳健的生物标志物。