Interfollicular Hodgkin lymphoma (IHL) has been rarely reported in the literature and is recognized by the WHO Classification as a morphologic pattern sometimes seen in mixed cellularity classic Hodgkin lymphoma (CHL). The changes may be subtle due to preservation of architecture. We report a case of a 9-year-old male with IHL showing preserved follicular architecture but with the presence of interfollicular infiltrates consisting of eosinophils, plasma cells, and Hodgkin-Reed-Sternberg (HRS) cells. Immunophenotyping confirmed the morphologic suspicion for IHL. A discussion and review of the literature are offered. We conclude that IHL is a variant that requires a high index of suspicion, as it may be easily missed due to the subtle morphologic features and preserved architecture seen in most cases. We further emphasize that unexplained interfollicular infiltrates of eosinophils may be clues that should prompt a search of HRS cells and consideration of immunohistochemical staining if needed.

中文翻译：

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滤泡间经典型霍奇金淋巴瘤一例报告及文献综述

滤泡间霍奇金淋巴瘤 (IHL) 在文献中很少报道，并被 WHO 分类认可为有时见于混合细胞性经典霍奇金淋巴瘤 (CHL) 的形态学模式。由于建筑的保存，这些变化可能是微妙的。我们报道了一名患有 IHL 的 9 岁男性病例，其滤泡结构保留，但存在由嗜酸性粒细胞、浆细胞和霍奇金-里德-斯滕伯格 (HRS) 细胞组成的滤泡间浸润。免疫表型分析证实了对 IHL 的形态学怀疑。提供了文献的讨论和回顾。我们得出的结论是，IHL 是一种需要高度怀疑的变体，因为在大多数情况下，由于其微妙的形态特征和保留的结构，它很容易被忽视。我们进一步强调，不明原因的滤泡间嗜酸性粒细胞浸润可能是提示 HRS 细胞搜索的线索，并在需要时考虑免疫组织化学染色。