Nanomedicine has a profound impact on various research domains including drug delivery, diagnostics, theranostics, and regenerative medicine. Nevertheless, the clinical translation of nanomedicines for solid cancer remains limited due to the abundant physiological and pathological barriers in tumor that hinder the intratumoral penetration and distribution of these nanomedicines. In this article, we review the dynamic remodeling of tumor extracellular matrix during the tumor progression, discuss the impact of biophysical obstacles within tumors on the penetration and distribution of nanomedicines within the solid tumor and collect innovative approaches to surmount these obstacles for improving the penetration and accumulation of nanomedicines in tumor. Furthermore, we dissect the challenges and opportunities of the respective approaches, and propose potential avenues for future investigations. The purpose of this review is to provide a perspective guideline on how to effectively enhance the penetration of nanomedicines within tumors using promising methods.

中文翻译：

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肿瘤细胞外基质的生物物理特性对纳米颗粒瘤内命运的影响：对纳米药物设计的启示

纳米医学对药物输送、诊断、治疗诊断和再生医学等各个研究领域具有深远的影响。然而，由于肿瘤中存在丰富的生理和病理屏障，阻碍了纳米药物在肿瘤内的渗透和分布，纳米药物用于实体癌的临床转化仍然受到限制。在本文中，我们回顾了肿瘤进展过程中肿瘤细胞外基质的动态重塑，讨论了肿瘤内生物物理障碍对纳米药物在实体瘤内渗透和分布的影响，并收集了克服这些障碍以提高渗透和分布的创新方法。纳米药物在肿瘤中的积累。此外，我们剖析了各种方法的挑战和机遇，并提出了未来研究的潜在途径。本综述的目的是为如何使用有前景的方法有效增强纳米药物在肿瘤内的渗透提供前瞻性指导。