Neurodegenerative disorders are associated with chronic neuroinflammation, which contributes to their pathogenesis and progression. Resveratrol (RSV) is a polyphenolic compound with strong antioxidant and anti-inflammatory properties. In the present study, we investigated whether RSV could protect against cognitive impairment and inflammatory response in a mouse model of chronic neuroinflammation induced by lipopolysaccharide (LPS). Mice received oral RSV (30 mg/kg) or vehicle for two weeks, and injected with LPS (0.75 mg/kg) or saline daily for the last seven days. After two weeks, mice were subjected to behavioral assessments using the Morris water maze and Y-maze. Moreover, mRNA expression of several inflammatory markers, neuronal loss, and glial density were evaluated in the hippocampus of treated mice. Our findings showed that RSV treatment effectively improved spatial and working memory impairments induced by LPS. In addition, RSV significantly reduced hippocampal glial densities and neuronal loss in LPS-injected mice. Moreover, RSV treatment suppressed LPS-induced upregulation of NF-κB, IL-6, IL-1β, and GFAP in the hippocampus of treated mice. Taken together, our results highlight the detrimental effect of systemic inflammation on the hippocampus and the potential of natural products with anti-inflammatory effects to counteract this impact.

中文翻译：

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白藜芦醇可预防慢性神经炎症小鼠模型中脂多糖诱导的认知障碍和海马炎症反应

神经退行性疾病与慢性神经炎症有关，慢性神经炎症有助于其发病机制和进展。白藜芦醇 (RSV) 是一种多酚化合物，具有很强的抗氧化和抗炎特性。在本研究中，我们研究了 RSV 是否可以在脂多糖 (LPS) 诱导的慢性神经炎症小鼠模型中预防认知障碍和炎症反应。小鼠接受口服 RSV (30 mg/kg) 或载体两周，并在最后 7 天每天注射 LPS (0.75 mg/kg) 或盐水。两周后，使用 Morris 水迷宫和 Y 迷宫对小鼠进行行为评估。此外，还评估了治疗小鼠海马体中几种炎症标志物的 mRNA 表达、神经元损失和神经胶质密度。我们的研究结果表明，RSV 治疗可有效改善 LPS 引起的空间和工作记忆损伤。此外，RSV 显着降低了注射 LPS 的小鼠的海马神经胶质密度和神经元损失。此外，RSV 治疗抑制了 LPS 诱导的小鼠海马 NF-κB、IL-6、IL-1β 和 GFAP 的上调。总而言之，我们的结果强调了全身炎症对海马体的有害影响，以及具有抗炎作用的天然产品抵消这种影响的潜力。