Innate immunity may influence the onset of affective symptoms and alter sleep patterns in chronic inflammatory conditions. Here, we tested the prospective associations between baseline serum C-reactive protein (CRP), albumin, and CRP/albumin ratio (CAR, i.e., an emerging biomarker of disease activity), and self-reported symptoms of anxiety, depression, and insomnia at 1-year follow up in paediatric inflammatory bowel disease ( = 17). After controlling for baseline values, CAR (ρ = 0.591, = 0.026) predicted anxiety symptoms, while albumin predicted both anxiety (ρ = -0.687, = 0.007) and insomnia symptoms (ρ = -0.648, = 0.012). Current findings preliminarily suggest that inflammation may influence anxiety and sleep disturbance in paediatric IBD.

中文翻译：

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儿科炎症性肠病免疫生物标志物与焦虑、抑郁和失眠症状之间的关联：初步纵向分析

先天免疫可能会影响情感症状的发作并改变慢性炎症条件下的睡眠模式。在这里，我们测试了基线血清 C 反应蛋白 (CRP)、白蛋白和 CRP/白蛋白比率（CAR，即疾病活动的新兴生物标志物）与自我报告的焦虑、抑郁和失眠症状之间的前瞻性关联。小儿炎症性肠病的 1 年随访 (= 17)。控制基线值后，CAR（ρ = 0.591，= 0.026）预测焦虑症状，而白蛋白则预测焦虑（ρ = -0.687，= 0.007）和失眠症状（ρ = -0.648，= 0.012）。目前的研究结果初步表明炎症可能影响儿童 IBD 的焦虑和睡眠障碍。