Postpartum hemorrhage can lead to a variety of maternal complications. Tao Hong Si Wu Decoction (THSWD) is a traditional Chinese medicine used for treating gynecological diseases. However, the active ingredients of THSWD and its pharmacological mechanism of treatment for postpartum blood stasis still remained unclear. In this study, 201 components were identified in THSWD ethanol extract using ultra‐performance liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry, including 59 terpenoids and volatile oil, 61 Phenylpropanoids, 41 flavonoids, 22 alkaloids, and other 18 components. A total of 45 active compounds were identified in the blood and 33 active compounds were identified in the uterine. Taking the common components into the blood and into the uterus combined with network pharmacology. It was demonstrated that the active compounds can bind to the core target with good affinity through molecular docking. The results of this study will provide a reference for the quality control and pharmacodynamic material base research of THSWD.

中文翻译：

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超高效液相色谱-四极杆飞行时间质谱联合UNIFI研究桃红四物汤治疗产后瘀血的作用机制

产后出血可导致多种产妇并发症。桃红四物汤（THSWD）是一种用于治疗妇科疾病的中药。但THSWD的有效成分及其治疗产后瘀血的药理机制仍不清楚。本研究采用超高效液相色谱-四极杆飞行时间质谱技术，从THSWD乙醇提取物中鉴定出201种成分，包括59种萜类化合物和挥发油、61种苯丙素、41种黄酮类化合物、22种生物碱和其他18种成分。 。血液中总共鉴定出 45 种活性化合物，子宫中鉴定出 33 种活性化合物。将常见成分入血入宫，结合网络药理学。结果表明，通过分子对接，活性化合物能够以良好的亲和力与核心靶标结合。本研究结果将为THSWD的质量控制和药效物质基础研究提供参考。