Core–shell structure is a concentric circle structure found in nature. The rapid development of electrospinning technology provides more approaches for the production of core–shell nanofibers. The nanoscale effects and expansive specific surface area of core–shell nanofibers can facilitate the dissolution of drugs. By employing ingenious structural designs and judicious polymer selection, specialized nanofiber drug delivery systems can be prepared to achieve controlled drug release. The synergistic combination of core–shell structure and materials exhibits a strong strategy for enhancing the drug utilization efficiency and customizing the release profile of drugs. Consequently, multi-chamber core–shell nanofibers hold great promise for highly efficient disease treatment. However, little attention concentration is focused on the effect of multi-chamber core–shell nanofibers on controlled release of drugs. In this review, we introduced different fabrication techniques for multi-chamber core–shell nanostructures, including advanced electrospinning technologies and surface functionalization. Subsequently, we reviewed the different controlled drug release behaviors of multi-chamber core–shell nanofibers and their potential needs for disease treatment. The comprehensive elucidation of controlled release behaviors based on electrospun multi-chamber core–shell nanostructures could inspire the exploration of novel controlled delivery systems. Furthermore, once these fibers with customizable drug release profiles move toward industrial mass production, they will potentially promote the development of pharmacy and the treatment of various diseases.

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静电纺多室核壳纳米纤维及其控释行为：综述

核壳结构是自然界中发现的同心圆结构。静电纺丝技术的快速发展为核壳纳米纤维的生产提供了更多途径。核壳纳米纤维的纳米级效应和广阔的比表面积可以促进药物的溶解。通过采用巧妙的结构设计和明智的聚合物选择，可以制备专门的纳米纤维药物递送系统以实现受控的药物释放。核壳结构和材料的协同组合展现了提高药物利用效率和定制药物释放曲线的强有力策略。因此，多室核壳纳米纤维在高效疾病治疗方面具有广阔的前景。然而，很少有人关注多室核壳纳米纤维对药物控释的影响。在这篇综述中，我们介绍了多室核壳纳米结构的不同制造技术，包括先进的静电纺丝技术和表面功能化。随后，我们回顾了多室核壳纳米纤维的不同受控药物释放行为及其疾病治疗的潜在需求。基于静电纺丝多室核壳纳米结构的控释行为的全面阐明可以激发对新型控释系统的探索。此外，一旦这些具有可定制药物释放曲线的纤维走向工业化大规模生产，它们将有可能促进制药业的发展和各种疾病的治疗。