While neoadjuvant chemotherapy has become the standard of care for rectal cancers in most centres, there is much interest in neoadjuvant chemotherapy in colon cancer after the recent publication of the FOxTROT trial. The management of colon cancers seems to be heading down the same path as rectal cancer, where the radicality of surgery is replaced by chemotherapy intensification. The role of demanding procedures such as complete mesocolic excision with central venous ligation in this new paradigm of upfront chemotherapy remains uncertain and uninvestigated.

中文翻译：

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结肠癌：感觉不平衡？

虽然新辅助化疗已成为大多数中心直肠癌的护理标准，但在最近发表 FOxTROT 试验后，人们对结肠癌新辅助化疗产生了浓厚的兴趣。结肠癌的治疗似乎正在走与直肠癌相同的道路，即激进的手术被强化化疗所取代。在这种新的前期化疗模式中，诸如完全结肠系膜切除和中心静脉结扎等高要求手术的作用仍不确定且未经研究。