The underrepresentation of functional glial cells is a major challenge in brain organoid models. We developed an astroglia-enriched cortical organoid model that allows efficient generation of functional astrocytes and enables the formation of astroglial morphological subclasses with layer-specific gene expression profiles upon transplantation into the mouse brain.

中文翻译：

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植入小鼠体内的富含胶质细胞的皮质类器官捕获星形胶质细胞多样性

功能性神经胶质细胞的代表性不足是脑类器官模型的主要挑战。我们开发了一种富含星形胶质细胞的皮质类器官模型，该模型可以有效生成功能性星形胶质细胞，并在移植到小鼠大脑中时能够形成具有层特异性基因表达谱的星形胶质细胞形态亚类。