Introduction

During an acute migraine attack, changes in ventricular repolarisation parameters may occur due to an imbalance in the autonomic nervous system. Tpeak-tend (Tp-e) interval, Tp-e/QT ratio, and Tp-e/corrected QT (QTc) ratio are novel parameters of arrhythmogenesis and can be easily calculated in electrocardiography (ECG). The objective of this study is to demonstrate that novel ventricular repolarisation parameters can anticipate the risk of ventricular dysrhythmia in the migraine attack period.

Methods

This research was a prospective case–control study, which recruited a total of 144 participants, including 74 migraine patients and 70 healthy volunteers in the control group (CG) who met the criteria for migraine with or without aura. All participants underwent 12-lead ECG recordings, and the study compared the Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio with those of the CG.

Results

The average age of patients experiencing migraine attacks was 38.14 ± 10.82, with 58 (76%) of these patients being female. The Tp-e interval mean was higher in the migraine attack group than the CG, with a statistically significant difference discovered (74.22 ± 20.20 ms [ms] compared to 65.39 ± 11.33 ms, p = 0.001). However, there were higher mean Tp-e/QT and Tp-e/QTc ratios in the migraine attack group compared to the CG, and this difference was found to be statistically significant (0.20 ± 0.05 vs. 0.17 ± 0.03, p = 0.001, 0.18 ± 0.52 vs 0.16 ± 0.29, p = 0.003, respectively).

Conclusion

Prolonged Tp-e interval and elevated Tp-e/QT and Tp-e/QTc ratios were observed in migraine patients who presented to the emergency department, indicating a potential risk of ventricular dysrhythmia.

中文翻译：

---

急诊科急性偏头痛发作期间 Tpeak-end 间期、Tpeak-end/QT 和 Tpeak-end/Qtc 比值的评估

介绍

在急性偏头痛发作期间，由于自主神经系统的不平衡，可能会发生心室复极参数的变化。Tpeak-tend (Tp-e) 间隔、Tp-e/QT 比值和 Tp-e/校正 QT (QTc) 比值是心律失常发生的新参数，可以在心电图 (ECG) 中轻松计算。本研究的目的是证明新的心室复极参数可以预测偏头痛发作期间心室心律失常的风险。

方法

这项研究是一项前瞻性病例对照研究，共招募了 144 名参与者，其中包括 74 名偏头痛患者和 70 名符合有或无先兆偏头痛标准的对照组（CG）健康志愿者。所有参与者均接受 12 导联心电图记录，研究将 Tp-e 间期、Tp-e/QT 比值和 Tp-e/QTc 比值与 CG 进行比较。

结果

偏头痛发作患者的平均年龄为 38.14 ± 10.82 岁，其中 58 名患者（76%）为女性。偏头痛发作组的 Tp-e 间隔平均值高于 CG 组，存在统计学显着差异（74.22 ± 20.20 ms [ms] 与 65.39 ± 11.33 ms 相比，p  = 0.001）。然而，与 CG 相比，偏头痛发作组的平均 Tp-e/QT 和 Tp-e/QTc 比值较高，并且这种差异具有统计学意义（0.20 ± 0.05 vs. 0.17 ± 0.03，p  = 0.001 ，分别为 0.18 ± 0.52 与 0.16 ± 0.29，p  = 0.003）。

结论

在急诊科就诊的偏头痛患者中观察到 Tp-e 间期延长、Tp-e/QT 和 Tp-e/QTc 比值升高，表明存在室性心律失常的潜在风险。