In this study, we analyzed the potential associations of selected laboratory and anamnestic parameters, as well as 12 genetic polymorphisms (SNPs), with clinical COVID-19 occurrence and severity in 869 hospitalized patients. The SNPs analyzed by qPCR were selected based on population-wide genetic (GWAS) data previously indicating association with the severity of COVID-19. We confirmed the associations of disease with several clinical laboratory and anamnestic parameters and found an unexpected association between less severe disease and the loss of smell and taste. In most cases, selected SNP analysis supported earlier results by indicating genetic associations with hospitalization and disease severity, while the potential role of some previously unrecognized polymorphisms has also been observed. A genetic association was indicated between the presence of a reduced-function ABCG2 transporter variant and a less severe disease, which was also observed in diabetic patients. Our current results, which should be reinforced by larger studies, indicate that together with laboratory and anamnestic parameters, genetic polymorphisms may have predictive value for the clinical occurrence and severity of COVID-19.

中文翻译：

---

选定的多态性遗传变异与 COVID-19 疾病易感性和严重程度的潜在关联

在这项研究中，我们分析了选定的实验室和记忆参数以及 12 个基因多态性 (SNP) 与 869 名住院患者的临床 COVID-19 发生和严重程度的潜在关联。qPCR 分析的 SNP 是根据之前表明与 COVID-19 严重程度相关的全人群遗传 (GWAS) 数据选择的。我们证实了疾病与一些临床实验室和记忆参数的关联，并发现不太严重的疾病与嗅觉和味觉丧失之间存在意想不到的关联。在大多数情况下，选定的 SNP 分析通过表明与住院和疾病严重程度的遗传关联来支持早期结果，同时也观察到了一些以前未识别的多态性的潜在作用。功能降低的 ABCG2 转运蛋白变体的存在与不太严重的疾病之间存在遗传关联，这种情况也在糖尿病患者中观察到。我们目前的结果表明，与实验室和记忆参数一起，基因多态性可能对 COVID-19 的临床发生和严重程度具有预测价值，这一结果应该通过更大规模的研究得到加强。