Brushite calcium phosphate cement (brushite CPC) is a prospective bone repair material due to its ideal resorption rates in vivo. However, the undesirable mechanical property and bioactivity limited its availability in clinic application. To address this issue, incorporating polymeric additives has emerged as a viable solution. In this study, poly(ethylene glycol) dicarboxylic acid, PEG(COOH), was synthesized and employed as the polymeric additive. The setting behavior, anti-washout ability, mechanical property, degradation rate, and osteogenic capacity of brushite CPC were regulated by incorporating PEG(COOH). The incorporation of PEG(COOH) with carboxylic acid groups demonstrated a positive effect on both mechanical properties and osteogenic activity in bone repair. This study offers valuable insights and suggests a promising strategy for the development of materials in bone tissue engineering.

中文翻译：

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掺入聚乙二醇二羧酸同时调节透钙磷石磷酸钙骨水泥的机械​​/成骨能力

透钙磷石磷酸钙骨水泥（透钙磷石CPC）因其理想的体内吸收率而成为一种有前景的骨修复材料。然而，不良的机械性能和生物活性限制了其在临床应用中的可用性。为了解决这个问题，掺入聚合物添加剂已成为一种可行的解决方案。在这项研究中，合成了聚乙二醇二羧酸，PEG(COOH)，并用作聚合物添加剂。通过掺入PEG(COOH)来调节透钙磷石CPC的凝结行为、抗冲刷能力、力学性能、降解率和成骨能力。 PEG(COOH)与羧酸基团的结合对骨修复中的机械性能和成骨活性产生了积极影响。这项研究提供了宝贵的见解，并为骨组织工程材料的开发提出了一种有前景的策略。