A simple and facile microwave‐assisted method was developed for the synthesis of highly fluorescent nitrogen‐doped carbon quantum dots (N‐CQDs) using sucrose and urea. The produced quantum dots exhibited a strong emission band at 376 nm after excitation at 216 nm with quantum yield of 0.57. The as‐prepared N‐CQDs were characterized using Fourier‐transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM) images, and ultraviolet‐visible (UV‐visible) spectra. The average particle size was 7.7 nm. It was found that torsemide (TRS) caused an obvious quenching of the fluorescent N‐CQDs; so, they were used for its spectrofluorometric estimation. An excellent linear correlation was found between the fluorescence quenching of N‐CQDs and the concentration of the drug in the range of 0.10 to 1.0 μg/mL with limit of quantitation (LOQ) of 0.08 μg/mL and limit of detection (LOD) of 0.027 μg/mL. The method was successfully applied for the assay of the drug in its commercial tablets and spiked human plasma samples, and the results obtained were satisfactory. Complex GAPI was used for greenness assessment of the analytical procedures and the pre‐analysis steps. Interference likely to be introduced from co‐administered drugs was also studied.

中文翻译：

---

使用蔗糖和尿素制备高荧光氮掺杂碳量子点：绿色合成、表征以及用于测定片剂和血浆样品中的托拉塞米

开发了一种简单易用的微波辅助方法，用于使用蔗糖和尿素合成高荧光氮掺杂碳量子点（N-CQD）。所制备的量子点在216 nm激发后在376 nm处表现出强发射带，量子产率为0.57。使用傅里叶变换红外（FTIR）光谱、透射电子显微镜（TEM）图像和紫外可见（UV-可见）光谱对所制备的 N-CQD 进行了表征。平均粒径为7.7nm。发现托拉塞米（TRS）引起荧光N-CQDs明显猝灭；因此，它们被用于荧光光谱估计。在 0.10 至 1.0 μg/mL 范围内，N-CQD 的荧光猝灭与药物浓度之间存在良好的线性相关性，定量限 (LOQ) 为 0.08 μg/mL，检测限 (LOD) 为0.027微克/毫升。该方法成功应用于市售片剂和加标人血浆样品中该药物的测定，结果令人满意。复杂的 GAPI 用于分析程序和预分析步骤的绿色度评估。还研究了联合用药可能产生的干扰。