The search for novel water soluble red and near-IR photoinitiators for biomedical applications is a very important task. Here we describe the synthesis and photophysical properties of a water soluble complex of P(V) with tetra-15-crown-5-phthalocyanine bearing diethylene glycol monoethyl ether as axial ligand (). In addition to intense near-IR absorption, compound is characterized by a high quantum yield of singlet oxygen generation with moderate photostability. The combination of these properties with the discovered low dark and light induced cytotoxicity and negligible intracellular accumulation makes the complex promising for biophotopolymerization. Taking advantage of all the benefits of the complex, we demonstrate for the first time its successful application in the bulk photocuring of a water soluble polyethylene glycol diacrylate-based system with simultaneous preservation of mammalian cells viability.

中文翻译：

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磷 (V) 15-冠-5-酞菁作为水介质中一种有前途的无毒近红外光引发剂

寻找用于生物医学应用的新型水溶性红色和近红外光引发剂是一项非常重要的任务。在这里，我们描述了带有二甘醇单乙醚作为轴向配体的四-15-冠-5-酞菁的P(V)水溶性络合物的合成和光物理性质()。除了强烈的近红外吸收之外，该化合物还具有单线态氧产生的高量子产率和中等光稳定性的特点。这些特性与已发现的低暗和光诱导细胞毒性以及可忽略不计的细胞内积累相结合，使得该复合物有望用于生物光聚合。利用该复合物的所有优点，我们首次展示了其在水溶性聚乙二醇二丙烯酸酯系统的批量光固化中的成功应用，同时保留了哺乳动物细胞的活力。