BackgroundRapid eye movement sleep behavior disorder (RBD) is common in individuals with Parkinson’s disease (PD). In spite of that, the precise mechanism underlying the pathophysiology of RBD among PD remains unclear.ObjectiveThe aim of the present study was to analyze gray matter volumes (GMVs) as well as the changes of functional connectivity (FC) among PD patients with RBD (PD-RBD) by employing a combination of voxel-based morphometry (VBM) and FC methods.MethodsA total of 65 PD patients and 21 healthy control (HC) subjects were included in this study. VBM analyses were performed on all subjects. Subsequently, regions with significant different GMVs between PD patients with and without RBD (PD-nRBD) were selected for further analysis of FC. Correlations between altered GMVs and FC values with RBD scores were also investigated. Additionally, receiver operating characteristic (ROC) curves were employed for the evaluation of the predictive value of GMVs and FC in identifying RBD in PD.ResultsPD-RBD patients exhibited lower GMVs in the left middle temporal gyrus (MTG) and bilateral cuneus. Furthermore, we observed higher FC between the left MTG and the right postcentral gyrus (PoCG), as well as lower FC between the bilateral cuneus (CUN) and the right middle frontal gyrus (MFG) among PD-RBD patients in contrast with PD-nRBD patients. Moreover, the GMVs of MTG (extending to the right PoCG) was positively correlated with RBD severity [as measured by REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) score]. Conversely, the FC value between the bilateral CUN and the right MTG in PD-RBD patients was negatively correlated with RBDSQ score.ConclusionThis study revealed the presence replace with GMV and FC changes among PD-RBD patients, which were closely linked to the severity of RBD symptoms. Furthermore, the combination of basic clinical characteristics, GMVs and FC values effectively predicted RBD for individuals with PD.

中文翻译：

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帕金森病伴快速眼动睡眠行为障碍的 MRI 大脑结构和功能网络变化

背景快速动眼睡眠行为障碍 (RBD) 在帕金森病 (PD) 患者中很常见。尽管如此，PD中RBD病理生理学的确切机制仍不清楚。 目的本研究的目的是分析PD患者RBD的灰质体积（GMV）以及功能连接（FC）的变化。 PD-RBD）采用基于体素的形态测量（VBM）和FC方法相结合。方法本研究共纳入65名PD患者和21名健康对照（HC）受试者。对所有受试者进行 VBM 分析。随后，选择有和没有 RBD 的 PD 患者 (PD-nRBD) 之间 GMV 存在显着差异的区域进行 FC 的进一步分析。还研究了改变的 GMV 和 FC 值与 RBD 评分之间的相关性。此外，采用受试者工作特征（ROC）曲线来评估GMV和FC在识别PD RBD中的预测价值。结果PD-RBD患者的左侧颞中回（MTG）和双侧楔骨表现出较低的GMV。此外，我们观察到与 PD-RBD 患者相比，PD-RBD 患者的左侧 MTG 和右侧中央后回 (PoCG) 之间的 FC 较高，而双侧楔叶 (CUN) 和右侧额中回 (MFG) 之间的 FC 较低。 nRBD 患者。此外，MTG（延伸至右侧 PoCG）的 GMV 与 RBD 严重程度呈正相关（通过 REM 睡眠行为障碍筛查问卷 (RBDSQ) 评分测量）。相反，PD-RBD 患者双侧 CUN 与右侧 MTG 之间的 FC 值与 RBDSQ 评分呈负相关。 RBD 症状。此外，基本临床特征、GMV 和 FC 值的结合可以有效预测 PD 个体的 RBD。