Objective: The study aimed to evaluate the short-term clinical efficacy of percutaneous full-endoscopic transforaminal lumbar interbody fusion (Endo-TLIF) for lumbar degenerative diseases (LDD). Methods: From July 2020 to July 2021, 93 patients who underwent single-level lumbar fusion procedure were retrospective analysis. The patients were divided into Endo-TLIF group and transforaminal lumbar interbody fusion (TLIF) group. General demographic and perioperative data were recorded, the clinical outcomes were evaluated using visual analogue scale (VAS) and oswestry disability index (ODI). The disk height (DH) was compared between the two groups. Results: All of the surgical procedures were successfully completed, and the patients were followed for a minimum of 2 years. Intraoperative blood loss, drainage volume, time to independent ambulation and hospital length of stay in the Endo-TLIF group were significantly decreased in comparison with the open TLIF group (p < 0.05). The VAS for back pain on postoperative 7 day and ODI on postoperative 1 month were lower in the Endo-TLIF group than in the open TLIF group (P < 0.05), but no significant difference at 1 year and 2 years postoperatively (P > 0.05). The VAS score of leg pain had no demographic statistically significant differences between the groups (P > 0.05). The DH were significantly heightened after surgery compared to the preoperative height (p < 0.05). Conclusion: Endo-TLIF is a minimally invasive, safety surgery which can achieve comparable short-term effects as open TLIF. It may be a promising option for the treatment of LDD.

目的：本研究旨在评价经皮全内镜经椎间孔腰椎椎间融合术（Endo-TLIF）治疗腰椎退行性疾病（LDD）的短期临床疗效。方法：对2020年7月至2021年7月接受单节段腰椎融合术的93例患者进行回顾性分析。将患者分为Endo-TLIF组和经椎间孔腰椎椎间融合术（TLIF）组。记录一般人口统计学和围手术期数据，使用视觉模拟量表（VAS）和奥斯维斯特功能障碍指数（ODI）评估临床结果。比较两组之间的椎间盘高度（DH）。结果：所有手术均顺利完成，患者随访至少 2 年。与开放 TLIF 组相比，Endo-TLIF 组的术中失血量、引流量、独立下床时间和住院时间均显着减少（p  < 0.05）。Endo-TLIF 组术后 7 d 背痛 VAS 和术后 1 个月 ODI 低于开放 TLIF 组（P  < 0.05），但术后 1 年和 2 年差异无统计学意义（P  > 0.05） ）。各组间腿部疼痛 VAS 评分差异无统计学意义（P  > 0.05）。与术前相比，术后 DH 显着升高（p  < 0.05）。结论：Endo-TLIF是一种微创、安全的手术，可以达到与开放TLIF相当的短期效果。这可能是治疗 LDD 的一个有前途的选择。