For congenital heart disease patients, multiple imaging modalities are needed to discern anatomy and functional information such as differential blood flow. During cardiac catheterization, 3D rotational angiography (3DRA) can provide CTA-like images, enabling anatomical information and intraprocedural guidance. We seek to establish whether unique aspects of this technique can also generate quantitative functional blood flow information. We propose that systematic integration of 3DRA imaging, catheter hemodynamic information, and computational fluid dynamics (CFD), can provide quantitative information regarding blood flow dynamics and energetics, without additional imaging or procedures. We report a single center retrospective feasibility study comprising four patients with 3DRA imaging and a complete set of hemodynamic data. 3DRA was processed and segmented to reconstruct vascular regions of interest (ROI), and a computational grid for CFD modeling of blood flow through the ROI was generated. Blood flow was simulated by integrating catheter hemodynamic data to devise boundary conditions at vascular ROI inlets and outlets. The 3DRA-based workflow successfully generated key computational outputs commonly used for cardiovascular applications, including flow patterns, distribution fractions, wall shear stress. Computational outputs obtained were as detailed and resolved as those obtained from more commonly used CT or MR angiography. Accuracy was confirmed by comparing computed flow distributions with measurements for 2 cases, showing less than 2.0% error from the measured data. Systematic integration of catheter hemodynamic information, 3DRA imaging, and CFD modeling, provides an effective and feasible alternative to obtain important quantitative blood flow information and visualization, without additional imaging.

对于先天性心脏病患者，需要多种成像方式来辨别解剖结构和功能信息，例如血流差异。在心导管插入术期间，3D 旋转血管造影 (3DRA) 可以提供类似 CTA 的图像，从而提供解剖信息和术中指导。我们试图确定该技术的独特方面是否也可以生成定量的功能性血流信息。我们建议，3DRA 成像、导管血流动力学信息和计算流体动力学 (CFD) 的系统集成可以提供有关血流动力学和能量学的定量信息，而无需额外的成像或程序。我们报告了一项单中心回顾性可行性研究，包括四名患者的 3DRA 成像和一套完整的血流动力学数据。对 3DRA 进行处理和分割以重建感兴趣的血管区域 (ROI)，并生成用于对通过 ROI 的血流进行 CFD 建模的计算网格。通过整合导管血流动力学数据来模拟血流，以设计血管 ROI 入口和出口的边界条件。基于 3DRA 的工作流程成功生成了心血管应用常用的关键计算输出，包括流动模式、分布分数、壁剪切应力。获得的计算输出与更常用的 CT 或 MR 血管造影获得的计算输出一样详细和解析。通过将计算的流量分布与 2 个案例的测量值进行比较来确认准确性，显示与测量数据的误差小于 2.0%。导管血流动力学信息、3DRA 成像和 CFD 建模的系统集成，提供了一种有效且可行的替代方案，无需额外成像即可获得重要的定量血流信息和可视化。