This article provides a state-of-the-art review on landiolol, a medication that was recently submitted for 7 approvals. Focusing on its pharmacology, pharmacokinetics, and pharmacodynamics, the analysis underscores landiolol's unique attributes compared to conventional beta-blockers, particularly esmolol. As a sympatholytic agent, landiolol exhibits a short half-life, high cardioselectivity, and minimal impact on blood pressure, setting it apart in the realm of arrhythmia treatment. The review explores landiolol's potential applications, emphasizing scenarios where other beta-blockers may be limited. A detailed examination of its efficacy in preventing postoperative atrial fibrillation reveals promising results from clinical trials, suggesting its utility in diverse surgical settings. Additionally, the article delves into landiolol's role in rate control for atrial fibrillation/flutter, treatment of ventricular tachycardia/fibrillation, and its use in managing sepsis-related tachyarrhythmias. The evolving landscape of landiolol's applications extends beyond cardiac care, including potential anti-inflammatory, antioxidative, analgesic, and anticancer effects. While the outcomes from various studies are promising, challenges persist, requiring further research to optimize dosing strategies, identify optimal patient populations, and elucidate mechanisms underlying its diverse effects. The potential expansion of landiolol's applications highlights the importance of ongoing clinical investigation, offering a promising avenue for enhancing arrhythmia management and addressing broader medical needs.

中文翻译：

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兰地洛尔治疗心律失常：最新评论。

本文提供了兰地洛尔（landiolol）的最新评论，兰地洛尔是一种最近提交 7 项批准的药物。该分析重点关注其药理学、药代动力学和药效学，强调了兰地洛尔与传统 β 受体阻滞剂（尤其是艾司洛尔）相比的独特属性。作为一种交感神经阻滞剂，兰地洛尔具有半衰期短、心脏选择性高、对血压影响极小的特点，使其在心律失常治疗领域中脱颖而出。该综述探讨了兰地洛尔的潜在应用，强调了其他β受体阻滞剂可能受到限制的情况。对其预防术后心房颤动功效的详细检查揭示了临床试验的有希望的结果，表明其在不同手术环境中的实用性。此外，本文还深入探讨了兰地洛尔在心房颤动/扑动心率控制、室性心动过速/颤动治疗中的作用，以及其在治疗脓毒症相关快速性心律失常中的应用。兰地洛尔的应用不断发展，超出了心脏护理的范围，包括潜在的抗炎、抗氧化、镇痛和抗癌作用。虽然各种研究的结果充满希望，但挑战仍然存在，需要进一步研究来优化给药策略，确定最佳患者群体，并阐明其不同作用的机制。兰地洛尔应用的潜在扩展凸显了正在进行的临床研究的重要性，为加强心律失常管理和满足更广泛的医疗需求提供了一条有希望的途径。