Opioids are pain relievers that are often associated with opioid-induced constipation (OIC) that worsens with age. We performed a multicenter, retrospective analysis on the efficacy and safety of naldemedine, an opioid receptor antagonist, in treating OIC in patients with cancer (age >75 years).

中文翻译：

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纳尔德米定治疗老年癌症患者阿片类药物引起的便秘的疗效和安全性：一项回顾性研究。

阿片类药物是止痛药，通常与阿片类药物引起的便秘 (OIC) 有关，便秘会随着年龄的增长而恶化。我们对阿片受体拮抗剂纳尔德米定治疗癌症患者（年龄 >75 岁）OIC 的有效性和安全性进行了多中心回顾性分析。