Clopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke: The ATAMIS Randomized Clinical Trial.,JAMA Neurology

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Clopidogrel Plus Aspirin vs Aspirin Alone in Patients With Acute Mild to Moderate Stroke: The ATAMIS Randomized Clinical Trial.
JAMA Neurology ( IF 29.0 ) Pub Date : 2024-03-11 , DOI: 10.1001/jamaneurol.2024.0146
Hui-Sheng Chen ₁ , Yu Cui ₁ , Xin-Hong Wang ₁ , Yu-Tong Ma ₂ , Jing Han ₃ , Ying-Jie Duan ₄ , Jiang Lu ₅ , Li-Ying Shen ₆ , Yong Liang ₇ , Wei-Zhong Wang ₈ , Hui Wang ₉ , Yong Zhao ₁₀ , Jin-Tao Zhang ₁₁ , Yu-Lin Song ₁₂ , Xiao-Mei He ₁₃ , Run-Hui Li ₁₄ , Ding-Bo Tao ₁₅ , Jing Li ₁₆ , Shu-Man Huang ₁₇ , Ni Wang ₁₈ , Mei Hong ₁₉ , Chong Meng ₂₀ , Wei Zhang ₂₁ , Duo-Lao Wang ₂₂ , Thanh N. Nguyen ₂₃ , Shao-Yuan Chen ₂₄ , Li-Hong Zhao ₂₄ , Hong-Bo Xiao ₂₄ , Bing Han ₂₄ , Ying Hai ₂₄ , Zhong-Lian He ₂₄ , Li-Yang Zhang ₂₄ , Lian-Qiang Wang ₂₄ , Ping-Kang Pan ₂₄ , Dong-Qun Li ₂₄ , Yu-Tao Zhang ₂₄ , Dong-Yu Wang ₂₄ , Jing-Yu Li ₂₄ , Hong-Li Zhang ₂₄ , Xiao-Feng Qiu ₂₄ , Fu-Sheng Bai ₂₄ , Xu-Hai Gong ₂₄ , Jun Xu ₂₄ , Cheng-Guang Song ₂₄ , Zhi-Mei Yuan ₂₄ , Yan Du ₂₄ , Ping Zhang ₂₄ , Bao-Ying Sheng ₂₄ , Xiao-Hua Ju ₂₄ , Xin-Chen Zhu ₂₄ , Xiao-Hong Song ₂₄ , Ya-Jun Liu ₂₄ , Yan-Qin Guo ₂₄ , Hui-Ru Chen ₂₄ , Yong-Zhong Lin ₂₄ , Wei-Shu Xue ₂₄ , Zhao-Min Meng ₂₄ , Li-Yan Jiang ₂₄ , Qing-Hua Zhang ₂₄ , Hui-Min Liu ₂₄ , Zhong-Xin Xu ₂₄ , Chuan-Yu Liu ₂₄ , Ren-Lin Zou ₂₄ , Chun-Gang Zhao ₂₄ , Hui Li ₂₄ , Shuang-Yan Zhang ₂₄ , Zeng-Bao Wang ₂₄ , Ya-Fen Wei ₂₄ , Xue-Rong Qiu ₂₄ , Chang-Hao Jiang ₂₄ ,

Affiliation

Department of Neurology, General Hospital of Northern Theatre Command, Shenyang, China
Department of Neurology, Beipiao Central Hospital, Beipiao, China
Department of Neurology, Panjin Central Hospital, Panjin, China
Department of Neurology, General Hospital of Fuxin Mining Industry Group of Liaoning Health Industry Group, Fuxin, China
Department of Neurology, Linghai Dalinghe Hospital, Jinzhou, China
Department of Neurology, Tieling County Central Hospital, Tieling, China
Department of Neurology, Tieling Central Hospital, Tieling, China
Department of Neurology, Dandong Central Hospital, Dandong, China
Department of Neurology, Chinese People’s Liberation Army 966 Hospital, Dandong, China
Department of Neurology, Haicheng Traditional Chinese Medicine Hospital, Haicheng, China
Department of Neurology, Chinese People’s Liberation Army 960 Hospital, Taian, China
Department of Neurology, Anshan Changda Hospital, Anshan, China
Department of Neurology, Chaoyang Central Hospital, Chaoyang, China
Department of Neurology, The Affiliated Central Hospital of Shenyang Medical College, Shenyang, China
Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China
Department of Neurology, Donggang Central Hospital, Donggang, China
Department of Neurology, Dawa District People’s Hospital, Panjin, China
Department of Neurology, Wafangdian Central Hospital, Wafangdian, China
Department of Neurology, China Railway 19th Bureau Group Central Hospital, Liaoyang, China
Department of Neurology, Liaoyang County Central Hospital, Liaoyang, China
Department of Neurology, Liaoning Electrical Power Central Hospital, Shenyang, China
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
Department of Neurology, Radiology, Boston Medical Center, Boston, Massachusetts
for the ATAMIS investigators

Dual antiplatelet therapy has been demonstrated to be superior to single antiplatelet in reducing recurrent stroke among patients with transient ischemic attack or minor stroke, but robust evidence for its effect in patients with mild to moderate ischemic stroke is lacking.

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