Bioanalysis faces challenges in achieving fast, reliable, and point-of-care (POC) determination methods for timely diagnosis and prognosis of diseases. POC devices often display lower sensitivity compared to laboratory-based methods, limiting their ability to quantify low concentrations of target analytes. To enhance sensitivity, the synthesis of new materials and improvement of the efficiency of the analytical strategies are necessary. Enzyme-mimicking materials have revolutionized the field of the fabrication of new high-throughput sensing devices. The integration of microfluidic chips with analytical techniques offers several benefits, such as easy miniaturization, need for low biological sample volume, etc., while also enhancing the sensitivity of the probe. The use enzyme-like nanomaterials in microfluidic systems can offer portable strategies for real-time and reliable detection of biological agents. Colorimetry and electrochemical methods are commonly utilized in the fabrication of nanozyme-based microfluidic systems. The review summarizes recent developments in enzyme-mimicking materials-integrated microfluidic analytical methods in biomedical analysis and discusses the current challenges, advantages, and potential future directions.

中文翻译：

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将分析技术与模拟酶纳米材料相结合，用于制造用于生物医学分析的微流体系统

生物分析面临着实现快速、可靠的即时诊断 (POC) 测定方法以及时诊断和预测疾病的挑战。与基于实验室的方法相比，POC 设备通常表现出较低的灵敏度，限制了它们量化低浓度目标分析物的能力。为了提高灵敏度，需要合成新材料并提高分析策略的效率。模拟酶材料彻底改变了新型高通量传感设备的制造领域。微流控芯片与分析技术的集成具有多种优点，例如易于小型化、需要较低的生物样品体积等，同时还增强了探针的灵敏度。在微流体系统中使用类酶纳米材料可以为生物制剂的实时、可靠检测提供便携式策略。比色法和电化学方法通常用于制造基于纳米酶的微流体系统。该综述总结了生物医学分析中酶模拟材料集成微流控分析方法的最新进展，并讨论了当前的挑战、优势和潜在的未来方向。