Quercetin (QUE) is a powerful antioxidant and one of the common phenolic compounds found in plants, vegetables, and fruits, which has shown many pharmacological activities. The complex nature of the matrix in which QUE is found and its importance and potential uses in diverse applications force the researchers to develop selective and sensitive sensors. In the present work, a novel molecularly imprinted polymer (MIP)-based electrochemical sensor was fabricated for the selective and sensitive determination of the QUE in plant extracts and food supplements. Tryptophan methacrylate (TrpMA) was chosen as the functional monomer, whereas the photopolymerization (PP) method was applied using a glassy carbon electrode (GCE). Electrochemical and morphological characterizations of the developed sensor (TrpMA@QUE/MIP-GCE) were performed using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM). The linear range of the developed sensor was determined to be in the range of 1.0–25 pM, while the limit of detection (LOD) was calculated to be 0.235 pM. In conclusion, The TrpMA@QUE/MIP-GCE sensor might be classified as a promising platform for selective and sensitive determination of QUE not only in plant extracts but also in commercial food supplements because of its reliability, reproducibility, repeatability, stability, and fast response time.

中文翻译：

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高选择性和灵敏的分子印迹传感器，用于电化学测定悬钩子和草莓甲醇提取物中的槲皮素

槲皮素（QUE）是一种强大的抗氧化剂，是植物、蔬菜和水果中常见的酚类化合物之一，具有多种药理活性。 QUE 所在基质的复杂性及其在不同应用中的重要性和潜在用途迫使研究人员开发选择性和灵敏的传感器。在目前的工作中，我们制造了一种新型分子印迹聚合物（MIP）电化学传感器，用于选择性和灵敏地测定植物提取物和食品补充剂中的 QUE。选择色氨酸甲基丙烯酸酯（TrpMA）作为功能单体，而使用玻碳电极（GCE）应用光聚合（PP）方法。使用循环伏安法（CV）、电化学阻抗谱（EIS）和扫描电子显微镜（SEM）对所开发的传感器（TrpMA@QUE/MIP-GCE）进行电化学和形态表征。所开发传感器的线性范围确定为 1.0–25 pM，而检测限 (LOD) 计算为 0.235 pM。总之，TrpMA@QUE/MIP-GCE 传感器因其可靠性、重现性、可重复性、稳定性和快速性，可能被归类为一种有前途的平台，不仅可以选择性和灵敏地测定植物提取物中的 QUE，而且还可以用于商业食品补充剂中的 QUE。响应时间。