Aromatic disinfection by-products (DBPs) have garnered considerable interest in recent years for their potential carcinogenicity. However, efficient separation and enrichment of DBPs in complex samples is a challenge due to the extremely low content of aromatic DBPs and the complexity of sample matrices. In this study, a MIL-101(Cr)–NH@TAPB-DVA-COF hybrid material was prepared as the enrichment medium of membrane solid-phase extraction (M-SPE) to efficiently determine trace emerging aromatic DBPs. This medium exhibited excellent enrichment capacity and selectivity for aromatic DBPs because of the strong hydrogen bonding, π-π stacking and hydrophobic interactions. An efficient analytical method for five aromatic DBPs in juice drinks was successfully established by use of this hybrid material as the enrichment medium for M-SPE in combination with liquid chromatography tandem mass spectrometry (LC-MS/MS). The limits of detection of the established method were from 0.50 to 3.00 ng/L. Moreover, the method had been successfully used in real juice drinks to determine trace five aromatic DBPs with the spiked recoveries ranging from 84.1% to 125%. The method possessed high analytical sensitivity and accuracy for these five aromatic DBPs in juice drinks with the aid of the efficient M-SPE technology proposed.

中文翻译：

---

基于膜固相萃取的MIL-101(Cr)–NH2@TAPB-DVA-COF的制备用于果汁饮料中痕量芳香消毒副产物的高效富集和灵敏测定

近年来，芳香族消毒副产物（DBP）因其潜在的致癌性而引起了人们的广泛关注。然而，由于芳香族 DBP 含量极低且样品基质复杂，复杂样品中 DBP 的高效分离和富集是一个挑战。在本研究中，制备了MIL-101(Cr)–NH@TAPB-DVA-COF杂化材料作为膜固相萃取(M-SPE)的富集介质，以有效测定痕量新出现的芳香族DBP。由于强氢键、π-π堆积和疏水相互作用，该介质对芳香族 DBP 表现出优异的富集能力和选择性。以该杂化材料为M-SPE富集介质，结合液相色谱串联质谱（LC-MS/MS），成功建立了果汁饮料中5种芳香族DBP的高效分析方法。所建立方法的检出限为0.50～3.00 ng/L。此外，该方法已成功应用于真实果汁饮料中痕量五种芳香族DBP的测定，加标回收率在84.1%~125%之间。借助所提出的高效M-SPE技术，该方法对果汁饮料中的这5种芳香族DBP具有较高的分析灵敏度和准确度。