Wound healing involves four phases, namely hemostasis, inflammation, proliferation, and remodeling. The four meticulously and carefully programmed stages make up the normal biological process of wound healing in the human body. These phases must occur in the proper order and time for a wound to heal rapidly. Praseodymium oxide (PrO) was synthesized using combustion method. The fibers were electro-spun using a polymer solution containing Poly (vinyl alcohol) (PVA) and sodium alginate (SA) along with PrO. The morphology and the crystalline structure were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), FT-IR and scanning electron microscopy (SEM). PrO is incorporated into electro-spun fibers to enhance the wound healing process. The antimicrobial activity of PrO was tested by growth curve analysis, biofilm, colony count and well diffusion methods. Swelling, degradation, porosity and water vapor transmission rate were also performed. PrO incorporated fiber have shown a faster recovery rate and faster wound closure in scratch assay and MTT assay. PVA/SA/PrO fiber shows an enhanced wound healing in the in-vivo model.

中文翻译：

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通过加入 PrO2 PVA/SA 纤维加速伤口愈合

伤口愈合涉及四个阶段，即止血、炎症、增殖和重塑。这四个精心设计的阶段构成了人体伤口愈合的正常生物过程。这些阶段必须以正确的顺序和时间发生，以使伤口快速愈合。采用燃烧法合成氧化镨（PrO）。使用含有聚乙烯醇（PVA）、海藻酸钠（SA）以及 PrO 的聚合物溶液对纤维进行静电纺丝。使用透射电子显微镜（TEM）、X射线衍射（XRD）、FT-IR和扫描电子显微镜（SEM）对形态和晶体结构进行表征。 PrO 被纳入电纺纤维中以增强伤口愈合过程。通过生长曲线分析、生物膜、菌落计数和孔扩散法测试PrO的抗菌活性。还进行了膨胀、降解、孔隙率和水蒸气透过率。在划痕试验和 MTT 试验中，掺有 PrO 的纤维显示出更快的恢复速度和更快的伤口闭合。 PVA/SA/PrO 纤维在体内模型中显示出增强的伤口愈合能力。