Background/Aim: The ideal treatment of tooth avulsion is replantation. However, replanting teeth may lead to root resorption. Fibroblast growth factor-2 (FGF-2) is a cytokine that plays an important role in wound repair and tissue regeneration. Recently, FGF-2 has been studied a potential regenerative agent to prevent root resorption and ankylosis. The aim of this review is to analyze and summarize the currently available literature focusing on using FGF-2 based regenerative modalities to improve the outcomes of tooth replantation. Materials and Methods: An electronic search was conducted via PubMed/Medline, Google Scholar and ISI Web of Knowledge, using the Medical Subject Headings (MeSH) terms “Basic fibroblast growth factor,” “Fibroblast growth factor-2,” “tooth replantation,” and “replantation” for studies published between January 2001 and June 2021. Data was extracted and quality assessment was carried using the ARRIVE guidelines. Results: Nine animal studies were included in this review. In six studies, FGF-2 had a favorable effect on the tissue regeneration around roots of replanted teeth when compared to other treatment groups. However, quality assessment of the studies revealed many sources of bias and deficiencies in the studies. Conclusions: Within the limitations of this study, it may be concluded that FGF-2 may improve the outcomes of delayed replantation of avulsed teeth. However, more long-term animal studies, with improved experimental designs, and clinical trials are required to determine the clinical potential of the growth factor in improving the outcomes of delayed tooth replantation.

中文翻译：

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成纤维细胞生长因子-2 对牙齿再植结果的影响：动物研究的系统评价

背景/目的：牙齿撕脱的理想治疗方法是再植。然而，重新种植牙齿可能会导致牙根吸收。成纤维细胞生长因子-2 (FGF-2) 是一种细胞因子，在伤口修复和组织再生中发挥重要作用。最近，FGF-2 被研究为一种潜在的再生剂，可防止牙根吸收和强直。本综述的目的是分析和总结目前可用的文献，重点关注使用基于 FGF-2 的再生方式来改善牙齿再植的结果。材料和方法：通过 PubMed/Medline、Google Scholar 和 ISI Web of Knowledge 进行电子检索，使用医学主题词 (MeSH) 术语“碱性成纤维细胞生长因子”、“成纤维细胞生长因子-2”、“牙齿再植、 ”和“再植”用于 2001 年 1 月至 2021 年 6 月期间发表的研究。使用 ARRIVE 指南提取数据并进行质量评估。结果：本综述纳入了九项动物研究。在六项研究中，与其他治疗组相比，FGF-2 对再植牙齿根部周围的组织再生具有良好的影响。然而，研究的质量评估揭示了研究中的许多偏见和缺陷来源。结论：在本研究的局限性内，可以得出结论：FGF-2 可以改善撕脱牙延迟再植的结果。然而，需要更长期的动物研究、改进的实验设计和临床试验来确定生长因子在改善延迟牙齿再植结果方面的临床潜力。