There is evidence for a relationship between problematic cannabis use and depression although the directionality is unclear. The role of coping strategies mediating this relationship is of interest to better understand the mechanisms involved. The aim was to analyze the relationship between cannabis use and depression and its directionality, considering the mediating role of coping styles and their dependence on sex. Correlational and cross-sectional design. There were 261 cannabis users aged 18–57 years (M = 31.04), 36.66% women. Sex, cannabis dependence, coping styles, and depressive symptomatology were analyzed. Women scored higher in depression and men reported higher cannabis use, with a higher prevalence for moderate addiction. Higher severity of depressive symptomatology was found in cannabis users with dependence compared to those with moderate addiction. Active coping strategies were more common in the non-addicted group, while avoidant coping strategies were more common in the dependent group. The role of coping styles was observed to differ according to sex. In men, the relationship between depression and cannabis use was bidirectional, but the predictive capacity of each variable with respect to the others disappeared when considering avoidant coping as a mediator. Passive coping style is key in the relationship between depression and cannabis use. These findings have important implications for prevention and treatment of both problems.

有证据表明，有问题的大麻使用与抑郁症之间存在关系，尽管方向性尚不清楚。应对策略在调节这种关系中的作用对于更好地理解所涉及的机制很有意义。目的是分析大麻使用与抑郁之间的关系及其方向性，考虑应对方式的中介作用及其对性别的依赖性。相关性和横截面设计。年龄在 18-57 岁之间的大麻使用者有 261 名（M  = 31.04），其中女性占 36.66%。分析了性别、大麻依赖、应对方式和抑郁症状。女性抑郁症得分较高，男性大麻使用率较高，中度成瘾患病率较高。与中度成瘾者相比，有依赖性的大麻使用者的抑郁症状更严重。积极应对策略在非成瘾组中更常见，而回避应对策略在依赖组中更常见。据观察，应对方式的作用因性别而异。在男性中，抑郁症和大麻使用之间的关系是双向的，但当考虑回避应对作为中介时，每个变量相对于其他变量的预测能力就消失了。被动应对方式是抑郁症与大麻使用之间关系的关键。这些发现对于预防和治疗这两个问题具有重要意义。