Treatment of bone defects remains crucial challenge for successful bone healing, which arouses great interests in designing and fabricating ideal biomaterials. In this regard, the present study focuses on developing a novel fluffy scaffold of poly Lactide-co-glycolide (PLGA) composites with hydroxyapatite (HA) scaffold used in bone defect repair in rabbits. This fluffy PLGA/HA composite scaffold was fabricated by using multi-electro-spinning combined with biomineralization technology. In vitro analysis of human bone marrow mesenchymal stem cells (BMSCs) seeded onto fluffy PLGA/HA composite scaffold showed their ability to adhere, proliferate and cell viability. Transplant of fluffy PLGA/HA composite scaffold in a rabbit model showed a significant increase in mineralized tissue production compared to conventional and fluffy PLGA/HA composite scaffold. These findings are promising for fluffy PLGA/HA composite scaffolds used in bone defects.

Graphical Abstract

中文翻译：

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一种用于骨缺损修复的新型蓬松PLGA/HA复合支架

骨缺损的治疗仍然是骨成功愈合的关键挑战，这引起了人们对设计和制造理想生物材料的极大兴趣。在这方面，本研究重点开发一种新型蓬松的聚丙交酯-乙交酯（PLGA）复合材料与羟基磷灰石（HA）支架，用于兔骨缺损修复。这种蓬松的PLGA/HA复合支架是采用多重静电纺丝结合生物矿化技术制备而成。对接种到蓬松的 PLGA/HA 复合支架上的人骨髓间充质干细胞 (BMSC) 进行体外分析，显示其粘附、增殖和细胞活力的能力。与传统和蓬松的 PLGA/HA 复合支架相比，在兔模型中移植蓬松的 PLGA/HA 复合支架显示矿化组织产量显着增加。这些发现对于用于骨缺损的蓬松 PLGA/HA 复合支架来说是有希望的。

图形概要