mRNA therapeutics hold great promise for disease treatment, yet a key challenge lies in achieving site-specific mRNA delivery to maximize therapeutic efficacy while minimizing off-target side effects. This viewpoint delves into multiple complementary targeting strategies to achieve precise site-specific mRNA delivery, covering topics of administration routes, passive targeting, and active targeting. It highlights the critical importance of rationally designed nanocarriers for obtaining desired therapeutic effects and accelerating the clinical translation of mRNA therapeutics.

中文翻译：

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位点特异性 mRNA 递送的靶向策略

mRNA 疗法为疾病治疗带来了巨大的希望，但关键的挑战在于实现位点特异性 mRNA 递送，以最大限度地提高治疗效果，同时最大限度地减少脱靶副作用。该观点深入研究了多种互补的靶向策略，以实现精确的位点特异性 mRNA 递送，涵盖给药途径、被动靶向和主动靶向等主题。它强调了合理设计的纳米载体对于获得所需的治疗效果和加速 mRNA 疗法的临床转化至关重要。