More than ever, scientific progress in cancer research hinges on our ability to combine datasets and extract meaningful interpretations to better understand diseases and ultimately inform the development of better treatments and diagnostic tools. To enable the successful sharing and use of big data, the NCI developed the Cancer Research Data Commons (CRDC), providing access to a large, comprehensive, and expanding collection of cancer data. The CRDC is a cloud-based data science infrastructure that eliminates the need for researchers to download and store large-scale datasets by allowing them to perform analysis where data resides. Over the past 10 years, the CRDC has made significant progress in providing access to data and tools along with training and outreach to support the cancer research community. In this review, we provide an overview of the history and the impact of the CRDC to date, lessons learned, and future plans to further promote data sharing, accessibility, interoperability, and reuse.

中文翻译：

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NCI 癌症研究数据共享：经验教训和未来状态

癌症研究的科学进步比以往任何时候都更依赖于我们整合数据集和提取有意义的解释以更好地了解疾病并最终为更好的治疗和诊断工具的开发提供信息的能力。为了成功共享和使用大数据，NCI 开发了癌症研究数据共享 (CRDC)，提供对大量、全面且不断扩展的癌症数据集合的访问。CRDC 是一个基于云的数据科学基础设施，研究人员可以在数据所在的位置进行分析，从而无需下载和存储大规模数据集。过去 10 年来，CRDC 在提供数据和工具以及培训和外展以支持癌症研究界方面取得了重大进展。在本次回顾中，我们概述了 CRDC 的历史和迄今为止的影响、经验教训以及进一步促进数据共享、可访问性、互操作性和重用的未来计划。