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New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-03-15 , DOI: 10.1080/14756366.2024.2311818 Asmaa H. Mohamed 1 , Mohammed B. Alshammari 2 , Ashraf A. Aly 1 , Kamal U. Sadek 1 , Akil Ahmad 2 , Eman A. Aziz 1 , Amira F. El-Yazbi 3 , Eman J. El-Agroudy 4 , Marwa E. Abdelaziz 4
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-03-15 , DOI: 10.1080/14756366.2024.2311818 Asmaa H. Mohamed 1 , Mohammed B. Alshammari 2 , Ashraf A. Aly 1 , Kamal U. Sadek 1 , Akil Ahmad 2 , Eman A. Aziz 1 , Amira F. El-Yazbi 3 , Eman J. El-Agroudy 4 , Marwa E. Abdelaziz 4
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In this article, a new series of 2-((3,5-disubstituted-2-thioxo-imidazol-1-yl)imino)acenaphthylen-1(2H)-ones were synthesized. Imidazole-2-thione with acenaphthylen-one gave a hybrid scaffold that ...
中文翻译：
新型咪唑-2-硫酮与苊酮连接作为双 DNA 嵌入剂和拓扑异构酶 II 抑制剂：结构优化、对接和细胞凋亡研究
在本文中，合成了一系列新的2-((3,5-二取代-2-硫代-咪唑-1-基)亚氨基)苊-1(2H)-酮。咪唑-2-硫酮与苊酮提供了一种混合支架......
更新日期：2024-03-16
中文翻译：
新型咪唑-2-硫酮与苊酮连接作为双 DNA 嵌入剂和拓扑异构酶 II 抑制剂：结构优化、对接和细胞凋亡研究
在本文中，合成了一系列新的2-((3,5-二取代-2-硫代-咪唑-1-基)亚氨基)苊-1(2H)-酮。咪唑-2-硫酮与苊酮提供了一种混合支架......
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