LINC00839 has captured significant attention within a spectrum of human disorders, including acute lung injury, osteoarthritis, and childhood obesity. Notably, aberrant expression patterns of LINC00839 have been observed across diverse cancer tissues and cell lines. LINC00839 emerges as an oncogenic factor in tumorigenesis and exerts a positive influence on tumor-associated behaviors. Its therapeutic potential for various cancers is underscored by its modulatory impact on pivotal signaling pathways, such as PI3K/AKT, OXPHOS, and Wnt/β-catenin. Additionally, LINC00839's role in reducing sensitivity to drug and radiotherapy interventions presents opportunities for targeted intervention. Furthermore, elevated LINC00839 expression indicates advanced clinicopathological features and foretells unfavorable prognoses, as validated by publications and comprehensive analyses of tumor types using TCGA datasets. This review elucidates the multiple regulatory mechanisms and functional implications of LINC00839 in various diseases, especially malignancies, emphasizing its potential as a predictive biomarker and therapeutic target across multiple disease domains in humans.

中文翻译：

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LINC00839 在人类疾病中的作用：深入了解其监管作用和临床影响，特别关注癌症

LINC00839 在一系列人类疾病中引起了广泛关注，包括急性肺损伤、骨关节炎和儿童肥胖症。值得注意的是，在不同的癌症组织和细胞系中观察到 LINC00839 的异常表达模式。LINC00839 作为肿瘤发生中的致癌因子出现，并对肿瘤相关行为产生积极影响。它对多种癌症的治疗潜力因其对关键信号通路（如 PI3K/AKT、OXPHOS 和 Wnt/β-catenin）的调节作用而得到强调。此外，LINC00839 在降低对药物和放射治疗干预敏感性方面的作用为有针对性的干预提供了机会。此外，LINC00839 表达升高表明先进的临床病理学特征，并预示着不利的预后，这一点已通过出版物和使用 TCGA 数据集对肿瘤类型的综合分析得到验证。本综述阐明了 LINC00839 在各种疾病（尤其是恶性肿瘤）中的多种调控机制和功能意义，强调了其作为人类多个疾病领域的预测生物标志物和治疗靶点的潜力。