The objective of this work was to review comparisons of the efficacy of Ga-PSMA-11 (prostate-specific membrane antigen) PET/CT and multiparametric magnetic resonance imaging (mpMRI) in the detection of prostate cancer among patients undergoing initial staging prior to radical prostatectomy or experiencing recurrent prostate cancer, based on histopathological data. A comprehensive search was conducted in PubMed and Web of Science, and relevant articles were analyzed with various parameters, including year of publication, study design, patient count, age, PSA (prostate-specific antigen) value, Gleason score, standardized uptake value (SUV), detection rate, treatment history, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and PI-RADS (prostate imaging reporting and data system) scores. Only studies directly comparing PSMA-PET and mpMRI were considered, while those examining combined accuracy or focusing on either modality alone were excluded. In total, 24 studies comprising 1717 patients were analyzed, with the most common indication for screening being staging, followed by relapse. The findings indicated that Ga-PSMA-PET/CT effectively diagnosed prostate cancer in patients with suspected or confirmed disease, and both methods exhibited comparable efficacy in identifying lesion-specific information. However, notable heterogeneity was observed, highlighting the necessity for standardization of imaging and histopathology systems to mitigate inter-study variability. Future research should prioritize evaluating the combined diagnostic performance of both modalities to enhance sensitivity and reduce unnecessary biopsies. Overall, the utilization of PSMA-PET and mpMRI in combination holds substantial potential for significantly advancing the diagnosis and management of prostate cancer.

中文翻译：

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mpMRI 和 68Ga-PSMA PET 成像在原发性和复发性前列腺癌中作用的最新进展

这项工作的目的是回顾比较 Ga-PSMA-11（前列腺特异性膜抗原）PET/CT 和多参数磁共振成像 (mpMRI) 在根治性治疗前接受初始分期的患者中检测前列腺癌的效果根据组织病理学数据，进行前列腺切除术或经历复发性前列腺癌。在PubMed和Web of Science中进行了全面检索，并使用各种参数对相关文章进行了分析，包括发表年份、研究设计、患者人数、年龄、PSA（前列腺特异性抗原）值、格里森评分、标准化摄取值（ SUV）、检出率、治疗史、敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和 PI-RADS（前列腺影像报告和数据系统）评分。仅考虑直接比较 PSMA-PET 和 mpMRI 的研究，而那些检查组合准确性或单独关注任一模式的研究被排除在外。总共分析了 24 项研究，涉及 1717 名患者，最常见的筛查指征是分期，其次是复发。研究结果表明，Ga-PSMA-PET/CT 可以有效诊断疑似或确诊疾病患者的前列腺癌，并且两种方法在识别病变特异性信息方面表现出相当的功效。然而，观察到显着的异质性，强调了成像和组织病理学系统标准化的必要性，以减轻研究间的变异性。未来的研究应优先评估两种方式的综合诊断性能，以提高敏感性并减少不必要的活检。总体而言，PSMA-PET 和 mpMRI 的结合使用对于显着推进前列腺癌的诊断和治疗具有巨大的潜力。