The sequential change from totipotency to multipotency occurs during early mammalian embryo development. However, due to the lack of cellular models to recapitulate the distinct potency of stem cells at each stage, their molecular and cellular characteristics remain ambiguous. The establishment of isogenic naïve and primed pluripotent stem cells to represent the pluripotency in the inner cell mass of the pre-implantation blastocyst and in the epiblast from the post-implantation embryo allows the understanding of the distinctive characteristics of two different states of pluripotent stem cells. This review discusses the prominent disparities between naïve and primed pluripotency, including signaling pathways, metabolism, and epigenetic status, ultimately facilitating a comprehensive understanding of their significance during early mammalian embryonic development.

中文翻译：

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多能性信号通路与能量代谢之间的串扰。

从全能性到多能性的连续变化发生在早期哺乳动物胚胎发育过程中。然而，由于缺乏细胞模型来概括干细胞在每个阶段的独特功效，它们的分子和细胞特征仍然不明确。建立同基因幼稚和引发的多能干细胞来代表植入前囊胚内细胞团和植入后胚胎外胚层的多能性，可以了解两种不同状态的多能干细胞的独特特征。这篇综述讨论了幼稚多能性和引发多能性之间的显着差异，包括信号通路、代谢和表观遗传状态，最终有助于全面了解它们在早期哺乳动物胚胎发育过程中的重要性。