The photodynamic antimicrobial chemotherapy (PACT) activities of seven 1,3,5,7-tetramethyl-2,6-dibromoBODIPY dyes with 4-acetamidophenyl (2a), 2-iodophenyl (2b), 3-iodophenyl (2c), 4-iodophenyl (2d), 2-bromophenyl (2e), 5-bromothien-2-yl (2f), and methylphenyl ester (2g) meso-substituents were studied against Staphylococcus aureus through irradiation with a 530 nm Thorlabs M530L3 light emitting diode (LED) (110 mW.cm${}^{-2})$ to identify structure-property relationships related to modifying the meso-substituent. Significant differences are observed in the log${}_{10}$ reduction values obtained with 1 $\mu$M of 2a exhibiting the highest PACT activity with a value of 9.60 after 15 min of photoirradiation. In contrast, log${}_{10}$ reduction values < 1.20 were obtained after 60 min of photoirradiation for iodophenyl dyes 2b-2d. The data demonstrate that the singlet oxygen quantum yield of the dye is not the most important factor determining the PACT activity properties.

七种 1,3,5,7-四甲基-2,6-二溴BODIPY 染料与 4-乙酰氨基苯基 ( 2a )、2-碘苯基 ( 2b )、3-碘苯基 ( 2c )、4- 的光动力抗菌化疗 (PACT) 活性通过 530 nm Thorlabs M530L3 发光二极管 (LED) 照射，研究了碘苯基 ( 2d )、2-溴苯基 ( 2e )、5-溴噻吩-2-基 ( 2f ) 和甲基苯基酯 ( 2g )内消旋取代基对金黄色葡萄球菌的作用) (110 毫瓦·厘米${}^{-2}）$确定与修饰内消旋取代基相关的结构-性质关系。日志中观察到显着差异${}_{10}$使用 1 获得的减少值$\mu$光照射 15 分钟后， 2a的 M表现出最高的 PACT 活性，值为 9.60。相反，日志${}_{10}$碘苯基染料2b-2d光照射 60 分钟后获得的还原值 < 1.20 。数据表明，染料的单线态氧量子产率并不是决定 PACT 活性特性的最重要因素。