Registry studies have suggested associations between relationship status and fracture risk. We considered associations between relationship status and incident fracture in the Hertfordshire Cohort Study, comprising community-dwelling older adults, and explored associations between socioeconomic and lifestyle factors with relationship status. 2997 participants completed a baseline questionnaire (1998–2004) and clinic visit. Participants were followed up until December 2018 using Hospital Episode Statistics, which report clinical outcomes using codes from the 10th revision of the International Classification of Diseases (ICD-10); these codes were used to ascertain incident fractures. Relationship status (not currently married/cohabiting vs currently married/cohabiting) at baseline was examined in relation to incident fracture using Cox regression. Associations between baseline characteristics and relationship status were examined using logistic regression. Mean baseline age was 66.2 years. 80% were married/cohabiting at baseline; 15% had an incident fracture (mean (SD) follow-up duration: 14.4 (4.5) years). The following were related to greater likelihood of not being married/cohabiting: older age (women only); higher BMI (women only); current smoking; high alcohol consumption (men only); poorer diet quality (men only); lower physical activity; leaving school before age 15 (women only); and not owning one’s home. Those not married/cohabiting had greater risk of incident fracture compared to those who were (age-adjusted hazard ratios (95% CI) 1.58 (1.06, 2.38) among men, 1.35 (1.06, 1.72) among women); associations were attenuated after accounting for the above factors associated with relationship status in the corresponding sex. This suggests that differences in health profiles and lifestyle according to relationship status may explain the association between relationship status and fracture risk.

登记研究表明，关系状态与骨折风险之间存在关联。我们在由社区居住的老年人组成的赫特福德郡队列研究中考虑了关系状态与骨折事件之间的关联，并探讨了社会经济和生活方式因素与关系状态之间的关联。2997 名参与者完成了基线调查问卷（1998-2004 年）和临床访问。使用医院发病统计数据对参与者进行随访直至 2018 年 12 月，该统计数据使用国际疾病分类第十次修订版 (ICD-10) 的代码报告临床结果；这些代码用于确定骨折事件。使用 Cox 回归检查基线的关系状态（当前未婚/同居与当前已婚/同居）与骨折事件的关系。使用逻辑回归检查基线特征和关系状态之间的关联。平均基线年龄为 66.2 岁。80% 的基线时已婚/同居；15% 发生骨折（平均 (SD) 随访时间：14.4 (4.5) 年）。以下因素与不结婚/同居的可能性较大有关：年龄较大（仅限女性）；较高的体重指数（仅限女性）；目前吸烟；大量饮酒（仅限男性）；饮食质量较差（仅限男性）；体力活动减少；15 岁之前离开学校（仅限女性）；并且不拥有自己的房屋。与那些未婚/同居的人相比，那些未婚/同居的人发生骨折的风险更大（男性的年龄调整风险比（95％CI）为1.58（1.06，2.38），女性为1.35（1.06，1.72））；考虑到上述与相应性别的关系状态相关的因素后，关联性减弱。这表明，根据关系状态的健康状况和生活方式的差异可以解释关系状态与骨折风险之间的关联。