Superparamagnetic iron oxide nanoparticles (SPIONs) are nanoparticles used in a lot of applications such as batteries, and biomedical, … To obtain these nanoparticles, several techniques exist such as coprecipitation, thermal decomposition, sol–gel process but they have some advantages (synthesis in a water media, high crystallinity, high monodispersity) and disadvantages (using an organic solvent, large distribution of size, poor crystallinity). The goal of this work is to synthesize SPIONs for biomedical applications (for example as a contrast agent for the MRI): SPIONs should be stable in an aqueous media, monodisperse, and have good crystallinity and magnetic properties. To achieve this result, a microwave process is carried out. However, any study describes the microwave parameter on the synthesis of the nanoparticles. This work offers to determine the best conditions of the microwave to obtain ideal SPIONs for MRI. For this, an experimental design is carried out to determine these parameters thanks to different techniques of characterization (Transmission Electronic Microscopy, Dynamic Light Scattering, X‐ray diffraction, Thermogravimetric Analysis, magnetic characterizations). With the different results of these characterizations, the best conditions of the microwave are determined, and a simulation of all experiments is realized with a surface response.

中文翻译：

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通过微波工艺一步制备超顺磁性氧化铁纳米颗粒：通过实验设计优化微波参数

超顺磁性氧化铁纳米粒子 (SPION) 是一种用于许多应用的纳米粒子，例如电池、生物医学……为了获得这些纳米粒子，存在多种技术，例如共沉淀、热分解、溶胶-凝胶过程，但它们具有一些优点（在水介质，结晶度高，单分散性高），缺点（使用有机溶剂，粒径分布大，结晶度差）。这项工作的目标是合成用于生物医学应用的 SPION（例如作为 MRI 的造影剂）：SPION 在水介质中应稳定、单分散，并具有良好的结晶度和磁性。为了实现这一结果，需要进行微波处理。然而，任何研究都描述了纳米粒子合成中的微波参数。这项工作确定了微波的最佳条件，以获得用于 MRI 的理想 SPION。为此，通过不同的表征技术（透射电子显微镜、动态光散射、X射线衍射、热重分析、磁表征）进行实验设计来确定这些参数。根据这些表征的不同结果，确定了微波的最佳条件，并通过表面响应实现了所有实验的模拟。