MicroRNAs (miRNAs) are short, noncoding RNAs with essential roles in cellular pathways and are often associated with various diseases and stress conditions. Recently, they have been discovered in mitochondria, termed “mitomiRs,” with unique functions. Mitochondria, crucial organelles for energy production and stress responses, Dysregulated mitomiRs functions and expression has been evident in stress conditions such as cardiovascular and neurodegenerative. In this -analysis we have systematically identified miR-34a & miR-146a as possible potential biomarkers for affliction. A -analysis was conducted to assess the potential role of miR-34a and miR-146a, two specific mitomiRs, as biomarkers in stress-related conditions. The study followed PRISMA guidelines, involving comprehensive database searches in May and September 2023. Twelve studies meeting predefined inclusion criteria were selected, and data analysis included the evaluation of miR-34a and miR-146a expression levels in various stress conditions compared to control groups. We also performed Gene ontology (GO) and Pathway enrichment analysis to observe how mitomiRs affects our body. The -analysis revealed a significant increase in overall mitomiRs (miR-34a and miR-146a) expression levels in experimental groups experiencing different stress conditions compared to control groups (Z = 3.54, p < 0.05 using RevMan software). miR-34a demonstrated more pronounced upregulation and exhibited potential as a specific biomarker in certain stress-related conditions (Z = 2.22, p < 0.05). However, miR-146a did not show a significant difference, requiring further investigation in various stress-related contexts. The Analysis indicated a high degree of heterogeneity among the studies. This -analysis emphasises the importance of mitomiRs, especially miR-34a, as potential biomarkers in the intricate interplay between stress, mitochondrial function, and disease. The study opens new avenues for exploring miRNAs' diagnostic and therapeutic applications in stress-related diseases, highlighting their pivotal role at the crossroads of molecular biology, psychology, and medicine.

中文翻译：

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循环mitomiRs在应激反应中的荟萃分析：揭示miR-34a和miR-146a的重要性

MicroRNA (miRNA) 是短的非编码 RNA，在细胞通路中发挥重要作用，通常与各种疾病和应激状况相关。最近，在线粒体中发现了它们，称为“mitomiRs”，具有独特的功能。线粒体是能量产生和应激反应的关键细胞器，线粒体功能和表达失调在心血管和神经退行性疾病等应激条件下很明显。在这项分析中，我们系统地鉴定了 miR-34a 和 miR-146a 作为可能的疾病潜在生物标志物。进行分析以评估 miR-34a 和 miR-146a（两种特定的 mitomiR）作为应激相关病症中生物标志物的潜在作用。该研究遵循 PRISMA 指南，涉及 2023 年 5 月和 9 月的全面数据库搜索。选择了 12 项符合预定义纳入标准的研究，数据分析包括与对照组相比，评估各种应激条件下 miR-34a 和 miR-146a 的表达水平。我们还进行了基因本体论 (GO) 和通路富集分析，以观察 mitomiRs 如何影响我们的身体。分析显示，与对照组相比，经历不同应激条件的实验组的总体 mitomiR（miR-34a 和 miR-146a）表达水平显着增加（Z = 3.54，p < 0.05，使用 RevMan 软件）。 miR-34a 表现出更明显的上调，​​并在某些应激相关条件下表现出作为特定生物标志物的潜力（Z = 2.22，p < 0.05）。然而，miR-146a 没有表现出显着差异，需要在各种压力相关背景下进行进一步研究。分析表明研究之间存在高度异质性。该分析强调了 mitomiR，尤其是 miR-34a，作为应激、线粒体功能和疾病之间复杂相互作用的潜在生物标志物的重要性。该研究为探索 miRNA 在压力相关疾病的诊断和治疗应用开辟了新途径，强调了它们在分子生物学、心理学和医学十字路口的关键作用。