Gallbladder cancer (GBC) is a prevalent and deadly form of bile duct cancer, associated with poor prognosis. This study aimed to investigate the genetic factors contributing to the high incidence of GBC in certain geographical regions, particularly in the Northern and Eastern parts of India. The present case-control study focused on MMP2, a gene involved in tumor progression and metastasis, as a potential candidate in GBC pathogenesis.

中文翻译：

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MMP2 启动子变异在胆囊癌中的功能相关性：东印度人群的病例对照研究

胆囊癌（GBC）是一种常见且致命的胆管癌，预后不良。本研究旨在调查导致某些地理区域 GBC 高发的遗传因素，特别是在印度北部和东部地区。目前的病例对照研究重点关注 MMP2，一种参与肿瘤进展和转移的基因，作为 GBC 发病机制的潜在候选基因。