Ontogeny cannot be separated from mechanical forces. Cells are continuously subjected to different types of mechanical stimuli that convert into intracellular signals through mechanotransduction. As a member of the G protein-coupled receptor superfamily, adhesion G protein-coupled receptors (aGPCRs) have attracted extensive attention due to their unique extracellular domain and adhesion properties. In the past few decades, increasing evidence has indicated that sensing mechanical stimuli may be one of the main physiological activities of aGPCRs. Here, we review the general structure and activation mechanisms of these receptors and highlight the lesion manifestations relevant to each mechanosensitive aGPCR.

中文翻译：

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机械敏感粘附 G 蛋白偶联受体：来自健康和疾病的见解

个体发育不能与机械力分开。细胞不断受到不同类型的机械刺激，这些刺激通过机械转导转化为细胞内信号。作为G蛋白偶联受体超家族的一员，粘附G蛋白偶联受体（aGPCR）由于其独特的胞外结构域和粘附特性而引起了广泛的关注。在过去的几十年里，越来越多的证据表明，感知机械刺激可能是aGPCR的主要生理活动之一。在这里，我们回顾了这些受体的一般结构和激活机制，并重点介绍了与每种机械敏感 aGPCR 相关的病变表现。