Jorge Lobo's disease (JLD) and lepromatous leprosy (LL) share several clinical, histological and immunological features, especially a deficiency in the cellular immune response. Macrophages participate in innate and adaptive inflammatory immune responses, as well as in tissue regeneration and repair. Macrophage function deficiency results in maintenance of diseases. M1 macrophages produce pro-inflammatory mediators and M2 produce anti-inflammatory cytokines. To better understand JLD and LL pathogenesis, we studied the immunophenotype profile of macrophage subtypes in 52 JLD skin lesions, in comparison with 16 LL samples, using a panmacrophage (CD68) antibody and selective immunohistochemical markers for M1 (iNOS) and M2 (CD163, CD204) responses, HAM56 (resident/fixed macrophage) and MAC 387 (recently infiltrating macrophage) antibodies.

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Jorge Lobo 病和瘤性麻风病中巨噬细胞免疫表型的比较研究

Jorge Lobo 病 (JLD) 和瘤性麻风病 (LL) 有一些共同的临床、组织学和免疫学特征，尤其是细胞免疫反应缺陷。巨噬细胞参与先天性和适应性炎症免疫反应，以及组织再生和修复。巨噬细胞功能缺陷导致疾病持续。 M1巨噬细胞产生促炎介质，M2巨噬细胞产生抗炎细胞因子。为了更好地了解 JLD 和 LL 发病机制，我们使用全巨噬细胞 (CD68) 抗体和 M1 (iNOS) 和 M2 (CD163， CD204）反应、HAM56（常驻/固定巨噬细胞）和 MAC 387（最近浸润巨噬细胞）抗体。