The rate of early neurological deterioration (END) differs in different subtypes of ischaemic stroke. Previous studies showed gene is a novel susceptibility locus for the occurrence of atherosclerosis and thrombotic events. The objective of this research is to examine the efficacy that may have on the risk of END in large artery atherosclerotic (LAA) stroke. Tagged single nucleotide polymorphisms (SNPs) were identified by a strategy of fine-mapping. The genotyping of the selected SNPs was performed by SNPscan. The impact of on indicating the susceptibility of END in LAA patients was evaluated by binary logistic regression. The SNP–SNP interactions of for END was assessed by generalized multifactor dimensionality reduction (GMDR). A total of 1527 LAA stroke patients were recruited, 582 patients (38 %) experienced END. Compared to participants without END, participants experienced END were much older ( = 0.018), more likely to suffer pre-existing diabetes mellitus ( = 0.036), higher frequent in active tobacco users ( = 0.022) and had much higher median NIHSS on admission ( < 0.001). Rs4685423 was identified to be a predictor to the risk of END: the frequency of END in AA genotype patients is lower than that in AC or CC genotype patients (multivariate-adjusted, OR 0.63; 95 % CI 0.49–0.80; < 0.001). The SNP-SNP interactions analysis indicates rs4685423 has the greatest impacton the risk of END for LAA patients. The time from admission diagnosis to END onset in AA genotype patients is much later than that in CA or CC genotype patients (log-rank, = 0.005). In summary, the rs4685423 SNP is probably associated with the END risk in LAA stroke patients.

中文翻译：

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3p24.3 的变异可预测大动脉粥样硬化性卒中早期神经功能恶化的风险

缺血性中风不同亚型的早期神经功能恶化（END）发生率不同。既往研究表明基因是动脉粥样硬化和血栓事件发生的新易感位点。本研究的目的是检查对大动脉粥样硬化 (LAA) 中风的 END 风险可能产生的功效。通过精细作图策略识别标记的单核苷酸多态性 (SNP)。通过 SNPscan 进行所选 SNP 的基因分型。通过二元 Logistic 回归评估了对 LAA 患者 END 易感性的影响。 END 的 SNP-SNP 相互作用通过广义多因子降维 (GMDR) 进行评估。总共招募了 1527 名左心耳卒中患者，其中 582 名患者（38%）经历了 END。与没有经历过 END 的参与者相比，经历过 END 的参与者年龄更大 ( = 0.018)，更有可能患有既往糖尿病 ( = 0.036)，活跃吸烟者的频率更高 ( = 0.022)，入院时 NIHSS 中位数也更高 ( < 0.001）。 Rs4685423 被确定为 END 风险的预测因子：AA 基因型患者的 END 频率低于 AC 或 CC 基因型患者（多变量调整，OR 0.63；95 % CI 0.49–0.80；< 0.001）。 SNP-SNP 相互作用分析表明 rs4685423 对 LAA 患者的 END 风险影响最大。 AA 基因型患者从入院诊断到 END 发生的时间比 CA 或 CC 基因型患者晚得多 (log-rank, = 0.005)。总之，rs4685423 SNP 可能与 LAA 卒中患者的 END 风险相关。