Using a flap in a large wound with a very small area of exposed vital structures may be an excessive intrusion and cause unnecessary donor site morbidity. Dermal matrix (DuraGen) was applied onto critical areas where bone or tendons were exposed and a split skin graft was placed thereon. All patients had satisfactory wound closure without the need for a flap. DuraGen appears to be a safe, single-stage alternative, to a flap for the healing of complex wounds.

中文翻译：

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Duragen：用于处理次优伤口的真皮替代品

在大伤口上使用皮瓣，且暴露的重要结构面积很小，可能会造成过度侵入，并导致不必要的供体部位发病。将真皮基质（DuraGen）施加到骨或肌腱暴露的关键区域，并在其上放置裂开的皮肤移植物。所有患者的伤口闭合均令人满意，无需皮瓣。 DuraGen 似乎是一种安全、单阶段的皮瓣替代方案，可用于复杂伤口的愈合。